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    Progesterone is a hormone that's produced mainly by a woman's ovaries. It's one of the hormones that fluctuate with a woman's menstrual period. There is less progesterone after menopause.

    Men's adrenal glands and testes also make progesterone.

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    Different forms of progesterone are available by prescription. Progesterone is often used in:

    Many plants contain compounds related to progesterone. It's possible to buy products made from plant progesterone without a prescription.

    A form of progesterone made from plants is also available as a skin cream without a prescription.

    This article focuses on progesterone that's available without a prescription -- not the drug form of progesterone that requires a prescription.

    Why do people use progesterone?

    Over-the-counter progesterone cream has been marketed as a treatment for menopausal symptoms, including:

    It's also sometimes used by people to try to treat:

    The progesterone in these creams can effectively travel through the skin and into the bloodstream, according to research. In one study, menopausal women used 40 milligrams of cream twice daily, placing it on their arm, thigh, breast, or abdomen. Their blood levels of progesterone were as high as when they took progesterone capsules by mouth.

    Can you get progesterone naturally from foods?

    Many plants make compounds similar to progesterone which may or may not function like the purified progesterone chemical. The progesterone in creams bought without a prescription is made by processing ingredients from plants, such as yams.

    What are the risks of using progesterone?

    Side effects. Progesterone may cause side effects such as:

    • Headache
    • Changes in heart rate
    • Coughing
    • Depression
    • Fatigue
    • Menstrual changes
    • Confusion
    • Difficulty breathing
    • Vision changes
    • Vertigo
    • Low blood pressure

    It may also cause symptoms of an allergic reaction, such as:

    • Skin rash or itchy skin
    • Tightness in the chest
    • Tingling in the mouth or throat
    • Trouble breathing
    • Swelling in the hands or face

    Other possible side effects include:

    • Dizziness
    • Swelling
    • Digestive upset
    • Drowsiness

    Risks. Progesterone may raise your risk of:

    • Breast cancer
    • Ovarian cancer
    • Heart problems
    • Blood clotting problems
    • Stroke
    • Endometriosis
    • Uterine fibroids

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