NADH does make a difference. Basically, my problem is pain, fatigue, overtaxed brain, and progressive weakening of cellular functions. Unclear, shifty diagnoses for the past 12 years by doctors who don't give a damn(CFS, Fibromyalgia, Ankylosing Spondylitis, Fibrocystic breast... and the eternal 'anxiety-depression')now blending with ageing. Watch for whether you actually need it. If you don't (especially young males), it will push you too far, like caffeine or chocolate can. If you notice easily a beneficial effect, may be you do need it. Watch for dose. High-doses can be counter-productive and push you over the edge, push you down, unless you have alzheimer or parkinson. I take 5mg and that's plenty. I combine it with an aminoacid treatment. The best effect is to give enough energy to prevent high-need reactions: it helps strengthen my breathing muscles and sleep better for example. If I don't do any hard work (computer, physical labour, hiking, mental focus, social stress...), I take it at night, for more recovery deep sleep. Otherwise in the morning. I have taken it for 8 months, and find no side effect nor need to increase dose (yet at leaast). It works on cellular energy and thus is more effective than raising norepinephrine with nicotine, doesn't have the side-effects and smoke associated problems. It is basically a better treatment for adaptive 'failure' to cope than stress-sex hormones: does not run out. I agree with others: not a placebo effect, and the trouble isn't in the mind but in the exhauting oversuse of the brain-central-control, which ends up weaking the body, the cells. NADH compensates, gives a break to the exhausted brain, and helps the body without using it as a resource to fuel the brain. Don't bother with doctors who don't have an adequate intellectual framework to understand the 'ups & downs' that plague women more than men. Excellent NADH effect.Read More Read Less