What Are the Symptoms of Acute Myeloid Leukemia?

Medically Reviewed by Sabrina Felson, MD on December 10, 2022

Acute myeloid leukemia (AML)  is a cancer of immature blood cells. When the early myeloid cell matures normally, it will become either a mature white blood cell, red blood cell, or platelet. But in AML, immature, clonal myeloid cells are unable to differentiate normally--they stay immature and there are lots and lots of them so they eventually crowd out all normal myeloid precursor cells. You have three main types of blood cells:

  1. White blood cells fight infections.
  2. Red blood cells carry oxygen around your body.
  3. Platelets clot your blood when you're injured.

In the early stages of AML, as your body makes fewer healthy blood cells, you might feel like you've come down with the flu or get sick from infections more easily than normal. Symptoms can include:

  • Tiredness
  • Fever
  • Loss of appetite
  • Weight loss
  • Night sweats

A lot of other things can cause those symptoms, too. So you and your doctor would work together to find the cause.

Symptoms by AML Type

There are several forms of AML. Each affects a different kind of blood cell. The symptoms you have depend on the type of blood cell that's affected.

If you have fewer healthy red blood cells than normal, you'll have symptoms like these:

  • Tiredness
  • Weakness
  • Pale skin
  • Irregular heartbeat
  • Dizziness
  • Cold hands and feet
  • Shortness of breath
  • Headaches
  • Weight loss
  • Loss of appetite

If you have fewer healthy white blood cells than normal, you may get more infections than usual. These infections may take a long time to get better.

Infections can cause symptoms like these:

  • Fever
  • Weakness
  • Achy muscles
  • Fatigue
  • Diarrhea

If you have fewer platelets than usual, your blood may not clot as well as it should. You might have symptoms like these:

  • Easy bruising
  • Bleeding that can be hard to stop
  • Bleeding gums
  • Small red spots under your skin caused by bleeding
  • Nosebleeds
  • Sores that don't heal

Symptoms When AML Spreads

Leukemia cells can spread to other parts of your body and cause symptoms like these:

  • Balance problems
  • Blurred vision
  • Bone or joint pain
  • Numbness in your face
  • Seizures
  • Spots or a rash on your skin
  • Swelling in your belly
  • Swollen, bleeding gums
  • Swollen glands in your neck, groin, underarms, or above your collarbone

See Your Doctor

If you have any of these symptoms, see your doctor. You might have an illness like the flu or another viral illness., but it's best to get checked out just in case. Your doctor will ask what symptoms you've had and for how long you've had them. You may need to get blood tests and other types of tests to diagnose AML.

AML Complications

Because AML affects your blood cells, it can lead to problems like these:

Anemia, in which you don’t have enough red blood cells. These cells carry oxygen to all your organs and tissues. When you have anemia, your body may not get enough oxygen. You can feel tired, weak, and short of breath as a result.

Bleeding. If your platelets are affected, your blood may not clot normally. You may bruise or bleed more easily than usual. When you cut yourself or get a nosebleed, the bleeding might not stop easily. You can also bleed inside your body, which could be serious.

Weakened immune system. The white blood cells in your immune system normally find and attack invading germs. With AML, you have fewer healthy white blood cells available to fight infections.

If your immune system is weak, you’re more likely to get infections. When you do get sick, your body will be slower to heal.

To prevent infections, your doctor might recommend that you stay away from anyone who's sick and take antibiotics regularly. Staying up to date on your vaccinations can also prevent you from getting sick, but you may not be able to take “live” vaccines like the shingles vaccine. Your doctor will know which kind of vaccines are OK for you to get.

Show Sources


American Cancer Society: "Can Acute Myeloid Leukemia Be Found Early?" "How is Acute Myeloid Leukemia Diagnosed?" "Signs and Symptoms of Acute Myeloid Leukemia," "What Is Acute Myeloid Leukemia?"

American Society for Clinical Oncology: "Leukemia - Acute Myeloid - AML: Symptoms and Signs." Leukaemia Foundation: "Acute myeloid leukaemia (AML)."

Mayo Clinic: "Anemia: Symptoms and causes."

National Cancer Institute: "Adult Acute Myeloid Leukemia Treatment (PDQ) - Patient Version."

National Health Service: "Acute myeloid leukaemia - complications."

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