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    • The Trial-and-Error Process of Treatment-Resistant Depression

    What Can Make Antidepressants Less Effective?

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      Video

      What Leads to Treatment-Resistant Depression

      People with major depressive disorder are less likely to respond to the first antidepressant they are prescribed. Several things can cause that to happen.

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      Article

      What Is Treatment-Resistant Depression?

      Patience and persistence are key with treatment-resistant depression. Learn how long to stick with a medication, and options for managing this condition.

      Article

      Advances in Handling this Condition

      An expert in treatment-resistant depression shares successful treatment strategies doctors can try to help with TRD.

      Article

      Explore Medication Strategies

      Managing treatment-resistant depression requires the right medicine in the right dosage and taking it the right way. Learn about medication strategies.

      Article

      How the Ups and Downs Can Affect You

      Striking a balance to manage treatment-resistant depression can take a toll. Learn from one patient's journey and see how research and community can help.

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