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    • Depression
    • The Trial-and-Error Process of Treatment-Resistant Depression

    What Can Make Antidepressants Less Effective?

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      Video

      What Leads to Treatment-Resistant Depression

      People with major depressive disorder are less likely to respond to the first antidepressant they are prescribed. Several things can cause that to happen.

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      Article

      Addressing Substance Abuse and Ways to Help Prevent It

      Substance use can worsen your depression and make it harder to treat. Get the facts on substance use disorders and treatment-resistant depression.

      Article

      What Is Treatment-Resistant Depression?

      Patience and persistence are key with treatment-resistant depression. Learn how long to stick with a medication, and options for managing this condition.

      Article

      Who Is Most at Risk?

      Want to know why antidepressants may not work for you? Get the facts on risk factors for treatment-resistant depression.

      Article

      Race and the Role It Plays

      Depression in the Black community tends to be more severe and persistent, but why? Find out how racial issues in the health care system make it harder to get helpful treatment.

      See More on Depression From WebMD

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