Influenza Virus Vaccine Live/Selected Antiviral Agents Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Amantadine, baloxavir, oseltamivir, rimantadine, zanamivir may inactivate the vaccine before your body can develop immunity to the influenza virus.

What might happen:

You may not develop immunity to the influenza virus if it is administered with or within 48 hours of using amantadine, baloxavir, oseltamivir, rimantadine, or zanamivir or if you take amantadine, rimantadine, or zanamivir within 2 weeks of receiving the intranasal influenza vaccine.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know before you receive the intranasal influenza vaccine if you have taken amantadine, baloxavir, rimantadine, or zanamivir in the previous 48 hours. If you have received the intranasal influenza vaccine in the previous two weeks, let your healthcare professional know before you start amantadine, oseltamivir, rimantadine, or zanamivir.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Symmetrel (amantadine hydrochloride) US prescribing information. Endo Pharmaceuticals Inc. January, 2009.
  • 2.Tamiflu (oseltamivir phosphate) US prescribing information. Roche Laboratories, Inc. March, 2018.
  • 3.Flumadine (rimantadine hydrochloride) US prescribing information. Forest Pharmaceuticals, Inc. April, 2010.
  • 4.Relenza (zanamivir) US prescribing information. GlaxoSmithKline June, 2018.
  • 5.Xofluza (baloxavir) US prescribing information. Genentech USA, Inc. October, 2018.
  • 6.FluMist (influenza virus vaccine live, intranasal) US prescribing information. MedImmune LLC July, 2010.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.