Although this medication is used to treat a certain liver disease, it has caused serious (even fatal) worsening of liver function, especially when taken at a higher dose than recommended. Your doctor should prescribe your dose based on your medical condition and response to treatment. For some patients whose liver disease is more serious, the starting dose is decreased to once weekly. To lower your chance of side effects, follow your doctor's dosage instructions carefully.


This medication is used alone or in combination treatment for a certain liver disease (primary biliary cholangitis-PBC). This disease slowly destroys the bile ducts in the liver. When bile ducts are damaged, harmful substances can build up in bile and scar the liver. Obeticholic acid works by causing your liver to make less bile, and by helping bile flow out of the liver. Obeticholic acid may help slow worsening of primary biliary cholangitis and decrease symptoms such as tiredness, itchy skin, abdominal pain, and dry eyes and mouth.

How to use Obeticholic Acid Tablet

See also Warning section.

Read the Medication Guide provided by your pharmacist before you start taking obeticholic acid and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor. The dosage is based on your medical condition, lab tests, and response to treatment. If you have side effects, your doctor may direct you to temporarily stop taking this medication, or to take it less often. Ask your doctor or pharmacist if you are not sure about your dosage instructions.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day you have a scheduled dose. If your doctor has prescribed a once- or twice-weekly schedule, it may help to mark your calendar.

If you also take certain other drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take obeticholic acid at least 4 hours before or at least 4 hours after taking these medications. These products can keep you from absorbing obeticholic acid fully.

Tell your doctor if your condition does not get better or if it gets worse.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.