Uses

What is Ubrelvy used for?

Ubrelvy (ubrogepant) is commonly used for the treatment of migraine with or without aura. An aura may occur before or during a migraine attack, and can include sensory problems like seeing flashing lights or zigzag lines, having trouble speaking, or experiencing a tingling sensation.

Learn more about Treating Acute Migraines With Ubrelvy.

Ubrelvy may also be used for other conditions as determined by your healthcare provider.

How does Ubrelvy work (mechanism of action)?

Ubrelvy works by blocking a substance in the brain called calcitonin gene-related peptide (CGRP), which is involved in headache pain and can make headaches last longer. By blocking CGRP, Ubrelvy helps treat migraines.

How is Ubrelvy supplied (dosage forms)?

Ubrelvy is available in the following dosage forms that are taken by mouth.

  • 50 mg oral tablets
  • 100 mg oral tablets

How should I store Ubrelvy?

Ubrelvy should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Ubrelvy?

The most common side effects of Ubrelvy are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Nausea
  • Sleepiness

There may be other side effects of Ubrelvy that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Ubrelvy?

While less common, the most serious side effects of Ubrelvy are described below, along with what to do if they happen.

Severe Allergic Reactions. Ubrelvy may cause allergic reactions, which can be serious. Stop taking Ubrelvy and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Ubrelvy?

Allergies to Ingredients. People who are allergic to any of the following should not take Ubrelvy.

  • Ubrogepant
  • Ubrelvy
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Ubrelvy.

Drug Interactions. Ubrelvy should not be taken while you are using certain other medicines. Before taking Ubrelvy, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

What should I know about Ubrelvy before using it?

Do not take Ubrelvy unless it has been prescribed to you by a healthcare provider. Take it as prescribed.

Do not share Ubrelvy with other people, even if they have the same condition as you. It may harm them.

Keep Ubrelvy out of the reach of children.

Ubrelvy can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how Ubrelvy affects you.

You should keep a journal (or use a mobile app) to keep track of migraine attacks, along with when you take Ubrelvy. This will help you and your healthcare provider understand how well Ubrelvy works for you.

What should I tell my healthcare provider before using Ubrelvy?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Ubrelvy is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.

  • Kidney problems
  • Liver problems

Pregnancy. It is not known if or how Ubrelvy could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. If you become pregnant while using Ubrelvy, you can register for The EMPRESS Pregnancy Registry by calling 833-277-0206 or at www.empresspregnancyregistry.com. This registry collects safety information about the use of Ubrelvy during pregnancy.

Breastfeeding. It is not known if Ubrelvy passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take Ubrelvy while breastfeeding.

How can I get more information about Ubrelvy?

For more information about Ubrelvy, you can visit the manufacturer’s website at www.ubrelvy.com or call them at 844-663-3742.

Interactions

Does Ubrelvy interact with foods or drinks?

Tell your healthcare provider if you eat or drink any grapefruit products, such as grapefruit, grapefruit juice, or any juices that contain grapefruit. Ubrelvy interacts with grapefruit. You should not take a second dose of Ubrelvy within 24 hours if you eat or drink grapefruit products.

It is unknown if drinking alcohol will affect Ubrelvy. However, alcohol can trigger migraine attacks in some people. Also, the risk of sleepiness may be increased if you drink alcohol while taking Ubrelvy. Consult your healthcare provider for more information and medical advice.

Does Ubrelvy interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Ubrelvy.

  • Clarithromycin, which is a medicine used for bacterial infections
  • Ketoconazole, fluconazole (Diflucan), or itraconazole (Sporanox, Tolsura), which is a medicine used for fungal infections
  • Verapamil (Verelan, Verelan PM), which is a medicine used for high blood pressure
  • Cyclosporine (Gengraf, Neoral, Sandimmune, and others), which is a medicine to suppress your immune system
  • Ciprofloxacin (Cipro), which is a medicine used for bacterial infections
  • Fluvoxamine (Luvox), which is a medicine used for obsessive-compulsive disorder (OCD)
  • Rifampin, which is a medicine commonly used to treat an infection called tuberculosis
  • Phenytoin (Dilantin, Phenytek, and others), which is a medicine to control seizures
  • A barbiturate, such as phenobarbital, butalbital, or primidone, which is a medicine that may be used to treat insomnia, migraines, or seizures
  • Eltrombopag (Alvaiz), which is a medicine used to treat certain types of thrombocytopenia or anemia
  • Curcumin or turmeric, which is a supplement that may be used for anti-inflammatory effects
  • St. John’s wort, which is a supplement that may be used to treat depression
  • Quinidine, which is a medicine used for irregular heart rhythm
  • Carvedilol (Coreg), which is a medicine used for high blood pressure and certain heart conditions

Many other medicines may alter the blood levels of Ubrelvy. Tell your healthcare provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Ubrelvy. Always check with your healthcare provider.
 

Does Ubrelvy (ubrogepant) interact with other drugs you are taking?
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Overdose/Missed Dose

What should I do if I accidentally use too much Ubrelvy?

If you or someone else has used too much Ubrelvy, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Ubrelvy?

Ubrelvy is meant to be used only when needed. Take it as your healthcare provider recommends. Do not take double or extra doses.

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