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What Are Ocular Surface Diseases?

Medically Reviewed by Poonam Sachdev on August 22, 2022

If your eyes are often dry and itchy, there could be many causes. Issues like dry air and dehydration are common causes of dry eyes. But chronic dry eyes could be caused by an ocular surface disease (OSD).

What Are Ocular Surface Diseases?

Ocular surface diseases are conditions that affect and damage the surface layers of the eyes. Your eyes have many parts to them, but the ones most affected by OSDs are the cornea, the conjunctiva, and the glandular network.

The cornea. The cornea is the clear, dome-shaped lens that covers the front of the eye. The cornea’s job is to focus the light coming into your eye.

The conjunctiva. The conjunctiva is a clear membrane that lines the inside of your eyelids and covers the whites of your eyes. The conjunctiva produces a layer of mucus that covers your eyes and becomes a part of your tears. It also creates a barrier that helps keep microorganisms and foreign objects out.

The glandular network. The glandular network is made of the Meibomian glands. These glands are located along the edge of your eyelids, where your eyelashes are. The Meibomian glands produce oil that makes up a part of your tears.

Ocular Surface Disease List

There are a few types of ocular surface diseases. Dry eye is the most common, but other conditions like blepharitis, neurotrophic keratitis, ocular rosacea, and Meibomian gland dysfunction are included as well.

Dry eye. Dry eye is a condition in which your eyes either don’t form enough tears or don’t form functional tears. This can lead to eye infections and damage to the surface of your eyes, which can harm your quality of life.

Blepharitis. Blepharitis is when your eyelids become inflamed, usually as a result of clogged oil ducts near the base of your eyelashes. Although blepharitis itself usually doesn’t cause any issues with your vision, it’s uncomfortable and it can lead to issues like eyelash or eyelid skin problems, dry eyes, styes, chronic pinkeye, corneal injury, or a chalazion. A chalazion is a blockage that can cause swelling and a hard lump in your eyelid.

Neurotrophic keratitis. Neurotrophic keratitis is a degenerative condition caused by nerve impairment. This impairment leads to reduced sensitivity of your cornea. As a result, your eyes don’t instinctively close when they need to, which can result in dry eyes or damage to your cornea.

Ocular rosacea. Ocular rosacea is a type of rosacea that affects your eyes, causing itching, burning, and redness. It can lead to dry eye, blepharitis, and corneal complications that may lead to vision loss.

Meibomian gland dysfunction. Meibomian gland dysfunction is a common condition in which your Meibomian glands aren’t producing sufficient oil. It can cause dry eyes and eyelid inflammation.

Ocular Surface Disease Symptoms

Each type of OSD has its own symptoms, although many of them include dry eyes.

Symptoms of dry eyes may include: 

  • A stinging or burning feeling in your eyes
  • Eye redness
  • Watery eyes
  • Blurred vision
  • Stringy mucus in or around your eyes
  • Difficulty wearing contact lenses
  • Difficulty driving

Symptoms of blepharitis include:

  • Watery or red eyes
  • Crusted or sticky eyes
  • Itchy, red, or swollen eyelids
  • Frequent blinking
  • Sensitivity to light
  • Blurred vision

Symptoms of neurotrophic keratitis may include:

  • Red or dry eyes
  • Blurred vision
  • Sensitivity to light

Symptoms of ocular rosacea include:

  • Red, watery, itchy, or dry eyes
  • Blurred vision
  • Sensitivity to light
  • Dilated blood vessels on the whites of your eyes
  • Red or swollen eyelids
  • Frequent eye infections

Symptoms of Meibomian gland dysfunction include: 

  • Dry, burning, or itching eyes
  • Sticky or crusted eyes
  • Watery eyes
  • Redness
  • Light sensitivity
  • Blurry vision
  • Styes and chalazia

Because many of these conditions have similar symptoms, it’s important to talk with your doctor to get a proper diagnosis. The diagnostic tests that your doctor performs will depend on which symptoms you're having and what the doctor suspects your diagnosis may be. Diagnostic tests may include:

  • A comprehensive eye exam
  • A Schirmer test, which measures the volume of your tears
  • A dye test to test the surface condition of your eyes
  • An osmolarity test, which measures the composition of your tears
  • Other tear sample tests

Testing for neurotrophic keratitis may include:

  • Using an esthesiometer, a tool to measure sensation, to test your corneal sensitivity.
  • Direct examination of the cornea, possibly using dyes or a slit-lamp
  • In vivo confocal microscopy, a non-invasive technique for getting high-resolution images of the cornea at the cellular level
  • Magnetic resonance imaging (MRI) to rule out other causes or to determine the cause of the neurotrophic keratitis

Ocular Surface Disease Causes

The causes of OSDs differ between the types.

There are many causes of dry eyes, and many other OSDs can cause dry eyes. Other potential causes include:

  • Aging
  • Hormonal conditions
  • Autoimmune conditions
  • Certain medical conditions
  • Some medications
  • Allergies
  • Dry air
  • Vitamin A deficiency

Scientists aren’t exactly sure what causes blepharitis, but leading theories suggest that it may be associated with:

Neurotrophic keratitis can be a result of any condition that affects the corneal nerves. This may include one of the herpes viruses, topical medications, or surgery near the eye area.

As with rosacea of the skin, scientists don’t yet know the cause of ocular rosacea. Possible causes include:

  • Genetics
  • Environmental factors
  • Bacteria
  • Clogged glands
  • Eyelash mites

Some factors that can aggravate ocular rosacea are:

  • Alcohol
  • Hot or spicy food and drinks
  • Weather
  • High emotions
  • Hot baths or saunas
  • Strenuous exercise

Meibomian gland dysfunction is often due to age or hormonal changes. Other causes include:

  • High cholesterol
  • Pinkeye
  • Bacteria
  • Autoimmune diseases
  • Medications

Ocular Surface Disease Treatment

Each type of OSD has its own treatment plan. Your doctor will start by trying to find the cause of your OSD. That cause will then determine your treatment, which may include eye drops, ointments, eyelid scrubs, warm compresses, or artificial tears. 

What to Do if You Suspect You Have an Ocular Surface Disease

If you suspect that your dry eyes are caused by an OSD and not dry weather or dehydration, call your doctor or ophthalmologist right away.

Show Sources

SOURCES:

American Academy of Ophthalmology: “Cornea,” "Corneal Esthesiometry," “Eye Anatomy: Parts of the Eye and How We See,” “Meibomian Gland Dysfunction.”

American Association for Pediatric Ophthalmology and Strabismus: “Meibomian Gland Dysfunction and Treatment.”

Mayo Clinic: “Blepharitis,” “Dry eyes,” “Ocular rosacea.”

Merck Manual: “Overview of Conjunctival and Scleral Disorders.”

National Organization for Rare Diseases: “Neurotrophic Keratitis.”

Ohio State University Wexner Medical Center: “Program of Excellence for Dry Eyes and Ocular Surface Diseases.”

Optomoetrists Network: “Meibomian Gland Dysfunction."

Wills Eye Hospital: "Ocular Surface Disease."

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