Pain and fatigue that don't let up can make you cranky, anxious, and depressed. You may have trouble staying on task at work, taking care of your kids, or keeping up with cleaning, for example. Exercise or hobbies such as gardening may seem daunting. Because you're exhausted and in a bad mood, you may not want to visit with friends. Fortunately, treatments can help relieve symptoms so you can do what you enjoy.