Why Prostate Cancer Spreads

Reviewed by Brunilda Nazario, MD on October 13, 2020

Prostate cancer starts when cells in the prostate gland grow out of control. Those cells can spread to other parts of the body and affect healthy tissue.

This can happen for several reasons.

Early Treatment Failure

When prostate cancer is discovered early, treatment usually works. Most men are able to live cancer-free for many years.

But sometimes, treatment doesn't work and prostate cancer can slowly grow.  This can happen after surgery (called a radical prostatectomy) or radiation therapy.

Sometimes called a chemical recurrence, it's when the cancer survives inside the prostate or reappears and spreads to other tissues and organs. The cancer is usually microscopic and grows very slowly.

You and your doctor will work together to keep an eye on the cancer as it grows. You may come up with a new treatment plan.

Active Surveillance

Because prostate cancer cells usually grow very slowly, some men might not need treatment right away.

Your doctor might suggest something called active surveillance. That means instead of having surgery or radiation right away, you and your doctor will track your cancer for a while to see if it gets more serious. You'll have regular tests, like PSA levels, and possibly biopsies and MRI. And if your cancer gets more aggressive, you and your doctor will figure out the next steps.

This plan is usually for men who don't have symptoms and whose cancer is expected to grow slowly. It's also an option when surgery or radiation could be harmful.

Watchful Waiting

Another potential plan is watchful waiting. Like active surveillance, this avoids surgery and radiation, and you and your doctor watch the progress of your cancer. But with watchful waiting, you don't have regular testing.

Most often, this is the best option for people who don't want or can't have other cancer treatments, or those who have another serious medical condition. The risk with this approach is that the cancer might grow and spread between checkups. If it does, this could limit which treatment you could take and if your cancer can be cured.

Treatment Issues

Managing the Side Effects of Your Prostate Cancer TreatmentEverything from naps to ice packs to playing golf can help you feel better as you go through advanced prostate cancer treatment.88

SPEAKER: If you're having side

effects from your prostate

cancer treatment,

there are some things you can do

to get relief.

If you have bone pain,

hot and cold packs may ease

the ache.

Acupuncture and chiropractic

therapy have also been shown

to ease bone pain.

Medications like ibuprofen

and naproxen can help, too.

If you have hot flashes,

limit alcohol and hot drinks

and avoid spicy foods.

You might also benefit

from relaxing activities

like yoga, meditation, tai chi.

If you're dealing

with urinary incontinence,

ask your doctor about medicines

that help control urine flow.

Bladder training

and incontinence products might

also help.

Walking, swimming, golf,

and gardening are great ways

to combat fatigue.

30-minute naps can give you

an energy boost, too.

Fight nausea with dry cool foods

like toast, crackers, fruit,

and baked or boiled poultry.

Sit up, eat small meals,

and use ginger and peppermint

to ease vomiting.

When your skin is irritated,

use a gentle cleanser to avoid

further irritation.

You can also take

warm oatmeal baths to soak

your skin.

It's also a good idea to wear

loose-fitting clothes.

You can help

erectile dysfunction

with medication, injections,

implants, and erection devices.

Prostate cancer treatment can be

tough on your body.

Exercise, eat fruits

and veggies, and get plenty

of rest to maintain your health.

Cancer Council Victoria: “Prostate Cancer,” “Exercise.”<br>U.S. Department of Health and Human Services: “Hot flashes: What Can I Do?”<br>Seattle Cancer Care Alliance: “Exercise for men with prostate cancer.”<br>American Cancer Society: “Managing Fatigue or Weakness,” “Itching,” “Skin Rash,” “Treating Prostate Cancer Spread to Bones.”<br> “Eating when you have nausea and vomiting.”<br>Cancer Research: “Other ways of controlling sickness.”<br>Urology Care Foundation: “What is Erectile Dysfunction?”<br>Memorial Sloan Kettering Cancer Center: “What Can I Do to Cope with Hair Loss Due to Cancer Treatment?”<br>National Osteoporosis Foundation: “Food and Your Bones -- Osteoporosis Nutrition Guidelines.”/delivery/aws/5f/73/5f734b96-3312-3e77-a927-3eb395c69803/091e9c5e81fac378_vo-feature-managing-advanced-prostate-cancer_,4500k,2500k,1000k,750k,400k,.mp408/20/2020 12:00:0018001200photo of man doing yoga/webmd/consumer_assets/site_images/article_thumbnails/video/managing_advanced_prostate_cancer_video/1800x1200_managing_advanced_prostate_cancer_video.jpg091e9c5e81fac378

When you're diagnosed with cancer, as with any medical issue, it's important that you follow your treatment plan. That can mean scheduling regular checkups or, if radiation therapy is part of your treatment, being sure to go to all scheduled radiation visits.

If you miss some of them, you may have a greater chance that your cancer will spread.

In one study, for example, men who missed two or more sessions during their treatment had a greater chance that their cancer would come back. That was even though they eventually finished their course of radiation.

Late Diagnosis

Experts disagree on whether all men should get tested for prostate cancer and at what age screenings and the discussions about them should take place. Exams such as a prostate-specific antigen (PSA) test can help find cancer early. But there are questions about if the benefits of screening tests always outweigh the risks.

Some groups suggest that men at a normal risk for prostate cancer should have prostate screening tests when they turn 50. Some men might want to get tests earlier if they have risk factors that make them more likely to get prostate cancer.

The U.S. Preventive Services Task Force says that testing may be right for some men ages 55 to 69. They recommend that men talk to their doctor to discuss the potential risks and benefits of being tested.

The American Cancer Society recommends starting screenings at age 50, possibly earlier for men at a high risk. But first, men should discuss the pros and cons of the PSA test with their doctor to decide if it's right for them.

The American Urological Association says men ages 55 to 69 should talk to their doctor about the benefits and risks of a PSA test. The group also says:

  • PSA screening in men under age 40 is not recommended.
  • Routine screening in men between ages 40 and 54 at average risk is not recommended.
  • To reduce the harms of screening, a routine screening interval of 2 years or more may be preferred over annual screening in men who have decided on screening after a discussion with their doctor. As compared to annual screening, it is expected that screening intervals of 2 years preserve the majority of the benefits and reduce over-diagnosis and false positives.
  • Routine PSA screening is not recommended for most men over 70 or any man with less than a 10- to 15-year life expectancy.
  • There are some men ages 70 and older who are in excellent health who may benefit from prostate cancer screening.


Early prostate cancer usually has no symptoms. You may go to see the doctor when you have trouble urinating or pain in your hips and back. That's when prostate cancer may be discovered.

After that, your doctor may find out that your cancer has already spread beyond your prostate. If that's possible, you may be asked to take a test like a:

  • Bone scan
  • MRI
  • Ultrasound
  • CT scan
  • PET scan

Knowing if your cancer has spread will help your doctor work with you to choose your best treatment.

WebMD Medical Reference



American Cancer Society: "What Is Prostate Cancer?" "Watchful Waiting or Active Surveillance for Prostate Cancer," "Can Prostate Cancer Be Found Early?" "Signs and Symptoms of Prostate Cancer," "Key Statistics for Prostate Cancer."

Prostate Cancer Foundation: "Detecting Recurrence."

Harvard Medical School: "How to handle a relapse after treatment for prostate cancer."

National Cancer Institute: "Missed Radiation Therapy Sessions Increase Risk of Cancer Recurrence."

Mayo Clinic: "Prostate Cancer: Diagnosis,"  "Prostatitis."

Medscape: "Prostatitis Treatment & Management."

U.S. Preventive Services Task Force: "Prostate Cancer Screening Final Recommendation." "Chronic prostatitis and chronic pelvic pain syndrome."

American Urological Association: "Early Detection of Prostate Cancer."

Urology Care Foundation: "What's the Difference between Active Surveillance and Watchful Waiting when Treating Prostate Cancer?"

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