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There are many tools to treat atopic dermatitis (AD), both over-the-counter and prescription. You can try ointments and creams, or your doctor might suggest light therapy, or medications you take by mouth or get as a shot.

“There are constantly new treatments arising for atopic dermatitis that help lessen the burden and make treatment more effective,” says Geeta Patel, DO, founder of River Oaks Dermatology in Houston.

“Topical steroids are currently the mainstay of treatment, but they’re not always the most effective,” she says. What works well for one person doesn’t always work well for another. It may take time to find the right treatment.

Your doctor will make recommendations based on how severe your AD is and what areas of your body it are affects.

Best Treatments for Mild AD

“Mild atopic dermatitis usually involves topical therapy,” Patel says. If you have mild AD, your doctor may recommend one of these topical treatments:

Topical steroids. These creams or ointments relieve itch and ease inflammation. You put them on red or inflamed skin.

Topical steroids come in different strengths. Prescription steroids are usually more effective than over-the-counter products. The stronger it is, the more effective it may be to control inflamed skin. But it may have more side effects, like thinning your skin. Never use high-strength steroids on your face, armpits, or groin. For long-term use, get the lowest strength you can.

Topical calcineurin inhibitors. These creams and ointments have drugs that target your immune system to suppress inflammation and ease symptoms of itching in mild to moderate AD. They’re safe to use long-term. You put them on after you moisturize your skin, but some have rules about how soon you can use them afterward, so check the prescribing info. Examples are pimecrolimus (Elidel) and tacrolimus (Protopic).

Topical PDE4 inhibitors. These topical medications put the brakes on inflammation by blocking PDE4, an enzyme that triggers it. They reduce itching, redness, thickened skin, and oozing in mild to moderate AD. Right now there’s only one FDA-approved PDE4 inhibitor. It’s called crisaborole (Eucrisa). It’s approved for people ages 3 months and older, and you can use it long-term on all body parts.

If you have mild AD, your doctor may also tell you to:

  • Avoid triggers
  • Moisturize after bathing
  • Eat well
  • Manage stress
  • Sleep well

Best Treatments for Moderate to Severe AD

If you have moderate or severe AD, your doctor may recommend:

Wet wrap therapy. With this treatment, you wrap the affected skin with wet bandages after you apply moisturizers or topical corticosteroids. “Wet dressings help relieve itching, heal your skin, and help your creams or ointments to be more effective,” Patel says.

Your doctor will tell you how to do it and how often.

Oral medications. If creams don’t work, your doctor may recommend oral medication. “These work by slowing your immune system response, which can help to reduce the severity of symptoms,” Patel says.

Ultraviolet light or phototherapy. “Light therapy is often used to treat severe eczema that doesn’t respond to creams,” Patel says. The treatment exposes your skin to a controlled amount of natural sunlight, UVA, or UVB light to help with symptoms.

It usually involves going to your dermatologist’s office two or three times a week. Try to be patient. “It can sometimes take 1-2 months to take effect,” Patel says.

Abrocitinib (Cibinqo). This medication is a type of drug known as a JAK inhibitor. It’s approved for adults age 18 and up whose AD isn’t controlled by other treatments or who can’t use other treatments. It can help to clear skin and ease the itch of AD.  It does carry a risk of certain side effects, some of which can be serious. Talk with your doctor to be sure the benefits of this medication outweigh the risks.  

Dupilumab (Dupixent). This new lab-made medication can lessen inflammation, itching, how severe the disease is, and how far it has spread. You get it as a shot. Your doctor may recommend it if other treatments don’t work or if you can’t use products you rub onto your skin. “Trials have shown that most people experienced clear skin and reduced itching after about 16 weeks,” Patel says.

Tralokinumab-ldrm (Adbry). This is a biologic drug made in a lab from living organisms or products that come from living organisms. It’s an interleukin inhibitor, which means it blocks a protein called an interleukin from binding to a receptor on the surface of cells in your immune system and causing inflammation. You take it as a shot every 2 weeks. It’s approved for adults age 18 and up. 

Upacitinib (Rinvoq). Another JAK inhibitor, upacitinib is approved for children age 12 and up and adults when other treatments don’t control their AD.It can help to reduce itching and skin pain as well as clear the skin. It’s also linked to some possibly serious side effects, so you should talk with your doctor about whether this medication is right for you. 

Complementary Treatments for AD

These treatments may help ease your symptoms:

Mind-body practices. “Stress can worsen atopic dermatitis,” Patel says. Managing it can help cut down on flares. Try mindfulness meditation, yoga, tai chi, acupressure, hypnosis, or biofeedback, where you learn how to control things your body does, like your heart rate, to help you relax. These practices may also help if you scratch a lot.

Massage therapy. Massage is known to relieve stress, so it may cut back on flares. Choose a therapist who’s accredited and has experience working with people who have similar skin conditions. Make sure they don’t use oils or lotions that might trigger your AD or make it worse.

Coconut oil. Studies suggest applying coconut oil to your skin may lower staph bacteria and help prevent infection. “Apply it once or twice a day to damp skin,” Patel says. Choose virgin or cold-pressed oils, which don’t have chemicals.

Sunflower oil. “Sunflower oil boosts the skin’s barrier function, helping it retain moisture. It also has anti-inflammatory properties,” Patel says. Put it on twice a day, once after bathing so your skin is wet.

You may have heard that vitamins, supplements, and probiotics help with AD. But there’s not enough research to support taking them, and they may be harmful if you’re taking certain medications.

Lifestyle Tips for AD

Take these steps to help your treatments work better and relieve symptoms:

Take a lukewarm bath. Keep it to 10-15 minutes. Then pat your skin dry and apply moisturizer while it’s still damp.

Moisturize twice a day. Apply moisturizing cream at least twice a day to strengthen your skin’s barrier.

Prevent scratching. If your skin is itchy, try pressing it instead of scratching. “Covering the itchy area also helps stop you from scratching it,” Patel says.

Use a humidifier. “Hot, dry indoor air can dry out sensitive skin and worsen itching and flaking. A portable home humidifier or one attached to your furnace adds moisture to the air inside your home,” Patel says.

Avoid irritants. Choose mild soaps and detergents without dyes or perfumes. Avoid fragrances and cosmetics with chemicals, wool and synthetic clothes, and smoke. Keep your home clear of dust mites. Avoid foods that might trigger a flare.

Take allergy medication. Over-the-counter antihistamines like cetirizine (Zyrtec) and fexofenadine (Allegra) may help with itching. If your itch is severe, you can try diphenhydramine (Benadryl). It may make you drowsy, so take it at bedtime.

Show Sources


Annabelle Garcia, MD, Sonterra Dermatology.

Geeta Patel, DO, founder, River Oaks Dermatology, Houston.

American Academy of Allergy, Asthma, and Immunology: “Eczema (Atopic Dermatitis) Overview.”

Mayo Clinic: “Atopic dermatitis (eczema).”

National Eczema Association: “Atopic Dermatitis,” “Complementary and Alternative Treatments,” "FAQ – Adbry (Tralokinumab-ldrm),"  “Prescription Topicals.”

Beth Israel Lahey Health Winchester Hospital: “Lifestyle Changes to Manage Eczema.”

The Medical Letter: “Drugs for Atopic Dermatitis.”

News release, National Eczema Association.