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How does psoriasis affect the immune system?

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If you have psoriasis, one type of white blood cell, the B-cell, creates antibodies that destroy normal skin cells. Meanwhile, another type, the T-cell, makes too much of a protein called cytokine. This seems to affect the growth of skin cells. Normally, skin cells last  about a month, then they die, flake off, and get replaced by new ones. If you have psoriasis, this cell turnover happens in days instead of weeks. Layers of skin build up, and there's more blood flow to the area, which leads to redness and swelling. 

SOURCES:

Bruce E. Strober, MD, PhD, associate director of dermatopharmacology, department of dermatology, New York University School of Medicine; co-director, Psoriasis and Psoriatic Arthritis Center.

Jeffrey M. Weinberg, MD, director, clinical research center, St. Luke's-Roosevelt Hospital Center, New York City; assistant clinical professor of dermatology, Columbia University College of Physicians and Surgeons.

National Institute of Arthritis and Musculoskeletal and Skin Diseases.

American Academy of Dermatology.

National Psoriasis Foundation.

Abel, E.  , April 2005.  ACP Medicine

 

Reviewed by Debra Jaliman on July 21, 2020

SOURCES:

Bruce E. Strober, MD, PhD, associate director of dermatopharmacology, department of dermatology, New York University School of Medicine; co-director, Psoriasis and Psoriatic Arthritis Center.

Jeffrey M. Weinberg, MD, director, clinical research center, St. Luke's-Roosevelt Hospital Center, New York City; assistant clinical professor of dermatology, Columbia University College of Physicians and Surgeons.

National Institute of Arthritis and Musculoskeletal and Skin Diseases.

American Academy of Dermatology.

National Psoriasis Foundation.

Abel, E.  , April 2005.  ACP Medicine

 

Reviewed by Debra Jaliman on July 21, 2020

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