These drugs mimic menopause, getting rid of periods along with endometriosis symptoms. GnRH agonists, such as Lupron, Synarel, and Zoladex, block female hormones from being made. They can cause hot flashes, vaginal dryness, fatigue, mood changes, and bone loss. Danocrine works mainly by lowering estrogen. Side effects can include weight gain, smaller breasts, acne, facial hair, voice and mood changes, and birth defects. Elagolix (Orilissa) is another type of GnHR called an antagonist. It’s sometimes used to help slow the loss of bone density. Before you start taking it, talk to your doctor about the potential risks associated with it and whether or not it can help you.