Medically Reviewed by Traci C. Johnson, MD on July 31, 2020

What is Endometriosis?


Endometriosis happens when tissue normally found inside the uterus grows in other parts of the body. It may attach to the ovaries, fallopian tubes, the exterior of the uterus, the bowel, or other internal parts. As hormones change during the menstrual cycle, this tissue breaks down and may cause pain around the time of your period and longterm painful adhesions or scar tissue. More than 5.5 million American women have symptoms of endometriosis.

Endometriosis Symptoms


Pain just before, during, or after menstruation is the most common symptom. For some women, this pain may be disabling and may happen during or after sex, or during bowel movements or urination. It sometimes causes ongoing pain in the pelvis and lower back. Many women with endometriosis have mild or no symptoms, though. The symptoms may be related to the location of the growths.

Just Cramps or Endometriosis?


Most women have some mild pain with their menstrual periods. They may get relief from over-the-counter pain medications. If the pain lasts more than 2 days, keeps you from doing normal activities, or remains after your period is over, tell your doctor. 

Endometriosis and Teens


Endometriosis pain can begin with the first menstrual period. If your menstrual pain is strong enough to interfere with activities, you should consult your physician. The first step may be tracking the symptoms and taking pain medication, but ultimately the treatment options for teens are the same as for adults.

Endometriosis and Infertility


Sometimes the first -- or only -- symptom of endometriosis is trouble getting pregnant. Infertility affects about a third of women with the condition, for reasons that aren't well understood. Scarring may be to blame. The good news is that medical treatments can help someone overcome infertility, and pregnancy itself can relieve some symptoms of endometriosis.

Endometriosis or Fibroids?


Endometriosis is one cause of severe menstrual pain. But the pain can be caused by another condition, such as fibroids, which are noncancerous growths of the muscle tissue of the uterus. Fibroids can cause severe cramps and heavier bleeding during your period. The pain of endometriosis or fibroids can also flare up at other times of the month.

What Causes Endometriosis?


Doctors don't know why endometrial tissue grows outside of the uterus, but they have several theories. Heredity plays a role, and some endometrial cells may be present from birth. Another theory suggests that menstrual blood containing endometrial cells flows back through the fallopian tubes and into the pelvic cavity instead of out of the body. These cells are thought to stick to organs and keep growing and bleeding over time. Cells could also move to the pelvic cavity other ways, such as during a C-section delivery. A faulty immune system may fail to get rid of the misplaced cells.    

The brown cells seen here are endometrial cells removed from an abnormal growth on an ovary.

Endometriosis: Who Is at Risk?


The condition is more common in women who:

  • Are in their 30s and 40s
  • Have not had children
  • Have periods longer than 7 days
  • Have cycles shorter than 28 days
  • Started their period before age 12
  • Have a mother or sister who had endometriosis

Diagnosis: Tracking Symptoms


Your pattern of symptoms can help to identify endometriosis, including:

  • When the pain happens
  • How bad it is
  • How long it lasts
  • A change or worsening of pain
  • Pain that limits your activities
  • Pain during sex, bowel movements, or urination


Diagnosis: Pelvic Exam


Your doctor will do a pelvic exam to check your ovaries, uterus, and cervix for anything unusual. An exam can sometimes reveal an ovarian cyst or internal scarring that may be due to endometriosis. The doctor also looks for other pelvic conditions that could cause symptoms similar to endometriosis. 

Diagnosis: Pelvic Scans


Although it isn't possible to confirm endometriosis with scanning techniques alone, your doctor may order an ultrasound, CT scan, or MRI to help with diagnosis. These may be able to detect larger endometrial growths or cysts. The scans use sound waves, X-rays, or magnetic fields with radiofrequency pulses to create the images.

Diagnosis: Laparoscopy


Laparoscopy is the only sure way to determine if you have endometriosis. A surgeon inflates the abdomen with gas through a small incision in the navel. A laparoscope is a viewing instrument that's inserted through the incision. The surgeon can take small pieces of tissue for a lab to examine -- called a biopsy -- to confirm the diagnosis.

Treatment: Pain Medicine


Pain medications, such as acetaminophen, and nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen or naproxen, often help relieve the pain and cramping that comes with endometriosis. But these drugs only treat the symptoms and not the underlying endometriosis.

Treatment: Birth Control Pills


Oral contraceptives manage levels of estrogen and progestin, which make your menstrual periods shorter and lighter. That often eases the pain of endometriosis. Your doctor may prescribe pills to be taken continuously, with no breaks for a menstrual period, or progestin-only therapy. Progestin-only therapy can also be given by injection. Endometriosis symptoms may return after you stop taking the pills.

Treatment: Other Hormone Therapies


These drugs mimic menopause, getting rid of periods along with endometriosis symptoms. GnRH agonists, such as Lupron, Synarel, and Zoladex, block female hormones from being made. They can cause hot flashes, vaginal dryness, fatigue, mood changes, and bone loss. Danocrine works mainly by lowering estrogen. Side effects can include weight gain, smaller breasts, acne, facial hair, voice and mood changes, and birth defects. Elagolix (Orilissa) is another type of GnHR called an antagonist. It’s sometimes used to help slow the loss of bone density. Before you start taking it, talk to your doctor about the potential risks associated with it and whether or not it can help you.

Treatment: Excision


During a laparoscopy, the surgeon may remove visible endometrial growths or adhesions. Most women have immediate pain relief. A year after the surgery, though, about 45% of women will have a return of symptoms. The likelihood of symptoms returning rises over time. Hormone therapy started soon after surgery may improve the outcome.

Treatment: Open Surgery


Severe cases of endometriosis may require laparotomy, or open abdominal surgery, to remove growths, or a hysterectomy -- removal of the uterus and possibly all or part of the ovaries. Although this treatment has a high success rate, endometriosis still recurs for about 15% of women who had their uterus and ovaries removed.

Getting Pregnant With Endometriosis


Many women with endometriosis don't have trouble getting pregnant. But laparoscopic surgery can improve the pregnancy rate of women who have moderate to severe endometriosis. In vitro fertilization is an option if infertility persists. The sperm and egg are combined in a lab and the resulting embryo is implanted into the uterus.

Coping With Endometriosis


Although there is no way to prevent endometriosis, you can make lifestyle choices that will help you feel better. Regular exercise may help relieve pain by improving your blood flow and boosting endorphins, the body's natural pain relievers. Acupuncture, yoga, massage, and meditation also may help ease symptoms.

An End to Endometriosis?


For most women, endometriosis recedes with menopause. Some women find relief from endometriosis during pregnancy. In some cases, symptoms may simply go away. About one-third of women with mild endometriosis will find that their symptoms resolve on their own.

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American College of Obstetricians and Gynecologists.
Center for Young Women's Health, Children's Hospital of Boston.
Consumer Reports.
National Institute of Child Health & Human Development.
National Women's Health Information Center.