Over time, Addison's disease leads to these symptoms:
Chronic fatigue and muscle weakness.
Loss of appetite, inability to digest food, and weight loss.
Low blood pressure (hypotension) that falls further when standing. This makes a person dizzy, sometimes to the point of fainting.
Blotchy, dark tanning and freckling of the skin. This is most noticeable on parts of the body exposed to the sun, but also occurs in unexposed areas like the gums. Darkened skin is particularly likely to occur on the forehead, knees, and elbows or along scars, skin folds, and creases (such as on the palms).
Blood sugar abnormalities, including dangerously low blood sugar (hypoglycemia).
Nausea, vomiting, and diarrhea.
Inability to cope with stress.
Moodiness, irritability, and depression.
Intolerance to heat or cold.
Craving of salty foods.
Some of these symptoms may indicate conditions other than Addison's disease.
Because symptoms of Addison's disease progress slowly, they may go unrecognized until a physically stressful event, such as another illness, surgery, or an accident, worsens symptoms quickly. When this happens, it's called an Addisonian crisis. For one in four people with Addison's disease, this is the first time they realize they are ill. An Addisonian crisis is considered a medical emergency because it can be fatal.
Symptoms of an Addisonian crisis include:
Sudden penetrating pain in the lower back, abdomen, or legs
Severe vomiting and diarrhea, followed by dehydration