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Understanding Hemophilia -- the Basics
What Is Hemophilia?
Hemophilia refers to a group of inherited disorders that cause abnormal bleeding. The bleeding occurs because part of the blood -- called plasma -- has too little of a protein that helps blood clot.
Symptoms of hemophilia range from increased bleeding after trauma, injury, or surgery to sudden bleeding with no apparent cause. There are two types of hemophilia:
Understanding Hemophilia -- Prevention
At this time, there is no simple way to prevent hemophilia in someone who inherits a defective gene and thus produces too little clotting factor. If hemophilia runs in your family, you can be tested to see whether you carry the defective gene and receive counseling about your chance for having children with hemophilia. Gene therapy clinical trials began in early 1999 in an attempt to cure hemophilia, and in vitro fertilization may allow selection and implantation of embryos that lack the hemophilia...
Read the Understanding Hemophilia -- Prevention article > >
- Hemophilia A -- also called classic hemophilia -- is most common and occurs in about 85% of people with hemophilia.
- Hemophilia B -- also called Christmas disease -- is less common and occurs in about 15% of people with hemophilia.
Hemophilia A
Hemophilia A results from too little of a plasma protein called factor VIII, which helps blood clot. The greater the deficiency, the more severe the symptoms.
- Mild hemophilia: 5% to 25% of the normal factor VIII level
- Moderate hemophilia: 1% to 5% of the normal factor VIII level
- Severe hemophilia: Less than 1% of the normal factor VIII level
Most people who have hemophilia A have moderate or severe symptoms.
Hemophilia B
Hemophilia B results from too little of a plasma protein called factor IX, which helps blood clot. As in hemophilia A, hemophilia B can be mild, moderate, or severe. The greater the deficiency, the more severe the symptoms.
Recognizing Hemophilia
If there is no family history of hemophilia, an infant would not be tested for the condition. However, if there is a family history of hemophilia, specific tests can be done from an umbilical cord blood sample to see if a newborn infant has hemophilia. In fact, if the family desires, such testing can be done before a child is born.
For moderate or severe hemophilia, doctors and caregivers usually don't see any signs of the condition at birth or even for some time afterward. Symptoms in children may include:
- Heavy bleeding in a male baby after circumcision
- Excessive bruising or unusual bleeding during teething
- Swollen, bruised joints or muscles when learning to walk
- Frequent falls and bumps
For mild hemophilia, you may not have any noticeable symptoms until you undergo a dental procedure, which may cause you to bleed heavily, or you may not have any unusual bleeding unless you are injured in an accident or have surgery.
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