Butterbur May Be Effective Hay Fever Remedy
But Safety Questions Remain About Products Sold in U.S.
WebMD News Archive
Aug. 22, 2005 -- An herbal product derived from the leaves of the butterbur plant was found to be as effective for treating hay fever as a widely used antihistamine.
But concerns remain about the safety of unregulated products containing the plant extract sold in the United States.
The Swiss study was the largest ever to examine butterbur for the treatment of allergies. A total of 330 participants receive either the butterbur-extract product Ze339, high doses of the antihistamine Allegra, or placebo.
Swiss herbal medicine manufacturer Zeller AG, which markets Ze339, sponsored the research. The product is not sold in the United States, but other butterbur-extract products are.
Researcher Andreas Schapowal, MD, PhD, tells WebMD that this and other studies conducted by his research team show that the herbal product is both safe and effective. He adds that because it is also nonsedating, it could be a good choice for people who experience drowsiness when taking certain antihistamines.
Butterbur Used for Centuries
Butterbur (also known as blatterdock, flapperdock, or butterfly doc) is a plant found throughout Europe and Asia and parts of North America. It has been used in herbal remedies for centuries and in commercial medicines in Europe for several decades.
In nature, the plant does contain chemicals that are considered toxins and may be carcinogenic. There have been isolated reports of serious liver problems occurring in people who took butterbur preparations containing high levels of these chemicals.
Schapowal says the product he tested is safe because it is derived exclusively from the heart-shaped leaves of the butterbur plant and not the root, as some other preparations are. Plants are also especially cultivated to make the herbal product.
In the newly published study, hay fever patients being treated at 11 centers throughout Switzerland and Germany received either Ze339 three times a day (totaling 8 milligrams), a single-daily 180-milligram tablet of Allegra, or a placebo.
The researchers reported that both active treatments were equally effective and more effective than placebo for relieving hay fever symptoms such as sneezing, nasal congestion, and itchy eyes and/or nose. Both active treatments were also well tolerated. The findings were reported in the June issue of the journal Phytotherapy Research.