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Allergies Health Center

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Antibiotics Do Not Reduce Symptoms of Sinus Infection

Medications Don't Speed Recovery, but May Increase Antibiotic Resistance
By Joanna Broder
WebMD Health News
Reviewed by Louise Chang, MD

Feb. 14, 2012 -- Patients may want to pause before asking for antibiotics to treat a sinus infection.

A new study involving more than 150 patients ages 18 to 70 suggests that the antibiotic amoxicillin may be no better than a placebo in improving symptoms for those with sinusitis -- a common inflammation of the nasal passages and sinuses.

Findings from the trial -- published in the Journal of the American Medical Association -- show that when adults with a standard case of sinusitis were treated with either a 10-day course of amoxicillin or a placebo, by the third day both groups fared about the same in terms of recovery.

“The major implication might be a paradigm shift in how these patients are cared for,” Jane Garbutt, MD, a research associate professor of medicine and pediatrics at Washington University School of Medicine in St. Louis, tells WebMD. “So most people didn’t derive any clinical benefit from the antibiotic, so most people likely don’t need any antibiotic treatment.”

Garbutt and her colleagues used CDC guidelines for the evaluation and treatment of adults with sinusitis, which suggested that doctors only prescribe antibiotic treatment for the condition when patients have moderately severe or severe symptoms.

All the patients in the new study met the clinical guidelines for having sinusitis -- they had sinus-related symptoms, for at least seven but less than 28 days, that included facial pain, nasal congestion, and cough.

Sinus infections are most often caused by viruses or bacteria. Antibiotics can be used to treat bacterial infections, but they do not treat viruses.

“Nobody disputes that some of these patients have a bacterial infection and would benefit from an antibiotic,” she says. “The problem is we don’t know who they are.”

Garbutt writes that 1 in 5 of all adult antibiotic prescriptions in the U.S. is for the treatment of sinusitis, “and we’re suggesting that might not be the best plan,” she says, adding that 80% of patients with sinusitis get better on their own within 10 days.

Better for Public Health

Study results may have implications for the country’s overall public health.

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