New Gout Drug Twice as Effective
Febuxostat More Effective at Reducing Uric Acid Levels Than Standard Gout Drug
WebMD News Archive
Works for People Who Can't Tolerate Allpurionol
Febuxostat has a different chemical structure than allpurinol, but it acts
on the same enzyme that causes uric acid to rise, Wortmann explains.
"It's more potent than allopurinol, more selective, and it can be used
in patients with kidney problems who cannot tolerate allopurinol," Wortmann
Though allopurinol has been used for 30 years and is considered to be a safe
drug, serious side effects can occur -- especially in patients with kidney
problems. These side effects are collectively known as allopurinol
hypersensitivity syndrome and include widespread rash, fever, mouth sores, poor
kidney function, liver inflammation, and other complications.
"It's an excellent agent for patients who can't tolerate or who have had
bad reaction to allopurinol," Wortmann says.