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New Gout Drug Twice as Effective

Febuxostat More Effective at Reducing Uric Acid Levels Than Standard Gout Drug

Works for People Who Can't Tolerate Allpurionol

Febuxostat has a different chemical structure than allpurinol, but it acts on the same enzyme that causes uric acid to rise, Wortmann explains.

"It's more potent than allopurinol, more selective, and it can be used in patients with kidney problems who cannot tolerate allopurinol," Wortmann says.

Though allopurinol has been used for 30 years and is considered to be a safe drug, serious side effects can occur -- especially in patients with kidney problems. These side effects are collectively known as allopurinol hypersensitivity syndrome and include widespread rash, fever, mouth sores, poor kidney function, liver inflammation, and other complications.

"It's an excellent agent for patients who can't tolerate or who have had bad reaction to allopurinol," Wortmann says.


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