Gout is caused
by too much
uric acid in the blood (hyperuricemia). The exact cause of hyperuricemia sometimes isn't
known, although inherited factors (genes) seem to
play a role.
Uric acid may
form crystals that build up in the joints. This causes the pain and other symptoms.
Gout can seem to flare up without
specific cause. Or it can be brought on by:
Certain conditions related to diet and body
weight, such as being overweight, eating a diet rich in
meat and seafood (high-purine foods), and drinking too much alcohol.
Medicines that may increase uric acid
concentration, such as regular use of aspirin or
niacin or using medicines that reduce the amount of salt and water in the
Major illness or certain medical conditions, such
as rapid weight loss or high blood pressure.
Having been born with a rare condition that
causes high blood uric acid levels. People with Kelley-Seegmiller syndrome or
Lesch-Nyhan syndrome have a partial or complete deficiency in an
enzyme that helps to control uric acid levels.