Certain things can either cause gout or make you more likely to get it.
Things you can't change
- Being male
- Having a family history of gout
- Having been born with a rare condition that causes high blood uric acid levels, such as Kelley-Seegmiller syndrome or Lesch-Nyhan syndrome
Medicines that may increase uric acid
- Regular use of aspirin (more than 1 or 2 aspirin a day) or niacin
- Diuretic medicines
- Chemotherapy medicines (usually used to treat cancer)
- Medicines that suppress the immune system, such as cyclosporine, that are used to prevent your body from rejecting an organ transplant
Conditions related to diet and body weight
- Moderate, regular, or heavy use of alcohol, especially beer.
- A diet rich in meat and seafood, which can be high in purines.
- Frequent episodes of dehydration.
- Very low-calorie diets.
Certain other conditions and diseases appear more often in people who have gout than in people who don't, though studies have not shown a clear relationship. Gout may share risk factors (such as obesity, hypertension, and high levels of triglycerides) with certain diseases, including:
- Kidney (renal) disease.
- High blood pressure.
- Lead poisoning.
- Hardening of the arteries (atherosclerosis).
- Conditions that cause an abnormal rapid turnover of cells, such as psoriasis, multiple myeloma, hemolytic anemia, or tumors.
- Heart disease.
- Acute illness or infection.
- Injury to a joint.
- Rapid weight loss, as might happen in hospitalized patients who have changes in diet or medicines.