1 Hit of Meth Is Too Much in Pregnancy
Researchers Say 1 Low Dose Affected Unborn Baby Mice
July 27, 2005 -- Even one low dose of methamphetamine affects a baby during
pregnancy, new research shows.
The "meth" test was done on mice, not people. Nearly 9 million
people in the U.S. have tried methamphetamine at some point in their lives, the
researchers write in Free Radical Biology and Medicine.
"It's pretty remarkable that a single low dose can have such an
effect," says Peter Wells, PharmD, in a news release.
Wells is a University of Toronto pharmacy and pharmacology professor. He and
his colleagues gave one low dose of methamphetamine (also called
"meth," "speed," "crystal," "Tina," and
"ice") to pregnant mice.
The mice's offspring had long-term problems, including muscle coordination.
Those problems weren't seen in the offspring of mice that got a saltwater shot
with no drugs.
Women are urged by doctors and health experts to take especially good care
of themselves during pregnancy. That means steering clear of illegal drugs (as
well as tobacco and alcohol) and getting prenatal care.
"We've known for a while that meth abuse during pregnancy is associated
with low birth weight, cleft palates, and other malformations," says Wells.
"But this is the first research demonstrating that even a single exposure
can cause long-term damage."
Babies born to the "meth mice" had muscle coordination problems that
lasted at least 12 weeks after birth, write the researchers.
Key Time Frame
"People usually think the last trimester of pregnancy is when developing
brain function is most susceptible to damage. But in this case, the brain is
also affected by methamphetamine even in the earlier embryonic period,"
Adults can also be harmed by meth. The toxic brain effects were different in
the adult mice, write the researchers.
Developing babies may be more vulnerable to free radicals, write the
researchers. Free radicals are damaging chemicals that can hurt cells' DNA.
The researchers link DNA damage in the baby mice to the single shot of meth
given during pregnancy.
Wells' team plans to study the effects of methamphetamine on women and
babies, states the news release. Of course, the scientists won't be giving
anyone meth. Those studies would only include women who admit using meth while