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Possible Painkiller Link to Birth Defects

Study Shows NSAIDs May Up Risk of Heart Birth Defects During Early Pregnancy

Other Concerns continued...

Instead, most ob-gyn's recommend that their patients take the pain reliever acetaminophen, such as Tylenol or a generic version of the drug.

Margaret Honein, PhD, MPH, an epidemiologist with the CDC's National Center on Birth Defects and Developmental Disabilities, says it is clear that more research is needed to determine the safety profile of NSAIDs and many other drugs during pregnancy.

"In general, we know less than we would like to know about most medications, both prescription and over-the-counter," Honein tells WebMD. "Pregnant women and breastfeedingwomen are usually excluded from clinical trials, so we often understand very little about a drug's impact during pregnancy when it reaches the market."

Honein and CDC colleagues have interviewed 24,000 mothers who gave birth to babies with birth defects since 1998 in an effort to learn more about the causes of congenital abnormalities. The National Birth Defects Prevention Study (NBDPS) is one of the largest research efforts to ever address the issue.

The impact of many different drugs, including NSAIDs, on pregnancy outcomes, is a focus of the study.

"There are many medical conditions that require medication during pregnancy," Honein says. "One of the goals of our research is to try and provide better information to women so that they know the risks, if any."

Until more is known, Honein says, the best advice for pregnant women is to limit medication use to drugs that are absolutely needed.

"Women should not take medications that they don't need during pregnancy, and they shouldn't take a medication without discussing it with their doctor," she says.

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