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Health & Pregnancy

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H1N1 Flu Shot Appears Safe During Pregnancy

But Shot May Slightly Increase Risk for Guillian-Barre Syndrome in People 6 Months or Older
WebMD Health News
Reviewed by Laura J. Martin, MD

July 10, 2012 -- New research brings reassuring news for women who received the swine flu vaccine while pregnant during the H1N1 flu pandemic of 2009.

Infants born in Denmark whose moms got the H1N1 shot were no more likely to have major birth defects or to be born too early than infants whose moms did not get the vaccine during their pregnancies.

But a second, related study found that Canadians aged 6 months or older who received the H1N1 vaccine were at a slightly higher risk for developing Guillain-Barre syndrome during the two months following the shot.

Guillain-Barre syndrome is a nervous system disorder. It can causes muscle weakness, loss of reflexes, and numbness or tingling in the arms, legs, face, and other parts of the body. Most people recover without any lasting damage. In severe cases, however, GBS can cause paralysis and death.

According to the study, about two people developed GBS for every 1 million who received the vaccine.

The swine flu vaccine of 1976 was also linked to an increased risk of GBS, with one case of GBS per 100,000 people receiving the vaccine.

The flu itself increases risk of GBS as well.

H1N1 Shot Not Linked to Major Birth Defects, Preterm Birth

In the Danish study, researchers analyzed rates of major birth defects, preterm birth, and restricted growth in the uterus for infants in Denmark delivered between Nov. 2, 2009, and Sept. 30, 2010. Of 53,432 infants, 13.1% were exposed to the vaccine during pregnancy.

Infants whose mothers received the vaccine were not at any greater risk for any of these outcomes. This was true regardless of which trimester in pregnancy their moms received the shot, but fewer women got vaccinated in the first trimester.

"We conclude that H1N1-vaccinated pregnancies are not at increased risk of these adverse events," says study author Anders Hviid, an epidemiologist at Statens Serum Institut in Copenhagen, Denmark. "Our study contributes to the information available on the safety of influenza vaccination in pregnancy, [but] it is by no means a complete evaluation of vaccination in pregnancy."

During the H1N1 flu pandemic of 2009, pregnant women were urged to get vaccinated against this new swine flu strain with an all-new shot. An estimated 2.4 million women were vaccinated against the H1N1 flu during pregnancy in the United States alone, according to information in the new study.

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