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Health & Pregnancy

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Popular Morning Sickness Drug Safe in Pregnancy: Study

Women taking metoclopramide can be reassured by the findings, expert says

WebMD News from HealthDay

By Dennis Thompson

HealthDay Reporter

TUESDAY, Oct. 15 (HealthDay News) -- The anti-nausea medication metoclopramide appears to be a safe and effective treatment for morning sickness, Danish researchers report.

More than 40,000 women exposed to metoclopramide while pregnant did not face any increased risk of birth defects or miscarriage, according to a study published Oct. 16 in the Journal of the American Medical Association.

"This is by far the largest study on metoclopramide safety in pregnancy, and as such it expands substantially on the published evidence," said co-author Dr. Bjorn Pasternak of the Statens Serum Institute in Copenhagen. "It found that metoclopramide use in pregnancy was not associated with increased risk of major adverse outcomes, including major malformations and fetal death, and as such supports what is known about the safety profile of this drug."

More than half of pregnant women experience nausea and vomiting, usually early in their pregnancy, the study authors noted.

Most women deal with these symptoms with little treatment, but about 10 percent to 15 percent eventually will require medication because they face more serious complications such as dehydration or weight loss.

But many pregnant women have grave concerns regarding any sort of nausea medication because of the horrific birth defects associated with the drug thalidomide, which was used to treat morning sickness in the late 1950s and early 1960s. Thalidomide's tragic history led to the strengthening of the U.S. Food and Drug Administration (FDA) and the development of regulations regarding medication use during pregnancy.

"There's a general feeling to take no medications during pregnancy," said Dr. Siobhan Dolan, associate professor of obstetrics and gynecology at Montefiore Medical Center in New York City and medical adviser to the March of Dimes. "The truth is in the first trimester when the organs are forming we're cautious about any medication the women take. But there's a growing appreciation that there can be risks to not treating symptoms like nausea and vomiting."

Metoclopramide, sold under the brand name Reglan, is one of the most commonly used prescription medications in pregnancy, the authors noted.

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