Standard Treatment Options for Stage 0 Bladder Cancer
Patients with stage 0 bladder tumors can be cured by a variety of treatments, even though the tendency for new tumor formation is high. In a series of patients with Ta or T1 tumors who were followed for a minimum of 20 years or until death, the risk of bladder cancer recurrence after initial resection was 80%. Of greater concern than recurrence is the risk of progression to muscle-invasive, locally-advanced, or metastatic bladder cancer. While progression is rare for patients with low-grade tumors, it is common among patients with high-grade cancers.
The bladder is a pouch in the urinary tract that stores urine after it is produced by the kidneys. The bladder is lined with specialized cells called transitional cells.
Bladder cancer often arises from these transitional cells. The cancer spreads by penetrating bladder muscle, infiltrating surrounding fat and tissue, and -- if untreated -- spreads to lymph nodes and other organs, such as the liver, lungs, or bones.
The earlier the cancer is diagnosed, the more limited it will likely be and...
One series of 125 patients with TaG3 cancers followed for 15 to 20 years reported that 39% progressed to more advanced-stage disease while 26% died of urothelial cancer. In comparison, among 23 patients with TaG1 tumors, none died and only 5% progressed. Risk factors for recurrence and progression are the following:[2,3,4,5,6]
Standard treatment options for stage 0 bladder cancer include the following:
Transurethral resection (TUR) with fulguration followed by an immediate postoperative instillation of intravesical chemotherapy.
TUR with fulguration.
TUR with fulguration followed by an immediate postoperative instillation of intravesical chemotherapy followed by periodic intravesical instillations of bacillus Calmette-Guérin (BCG).
TUR with fulguration followed by an immediate postoperative instillation of intravesical chemotherapy followed by intravesical chemotherapy.
Segmental cystectomy (rarely indicated).
Radical cystectomy (in rare, highly selected patients with extensive or refractory superficial high-grade tumors).
Transurethral resection (TUR) with fulguration followed by an immediate postoperative instillation of intravesical chemotherapy
TUR and fulguration are the most common and conservative forms of management. Careful surveillance of subsequent bladder tumor progression is important. Because most bladder cancers recur after TUR, one immediate intravesical instillation of chemotherapy after TUR is often administered. Numerous randomized controlled trials have evaluated this practice, and a meta-analysis of seven trials reported that a single intravesical treatment with chemotherapy reduced the odds of recurrence by 39% (odds ratio, [OR] 0.61; P < .0001).[7,8] However, although a single instillation of chemotherapy lowers the relapse rate in patients with multiple tumors, the majority still relapse. Such treatment is thus not sufficient by itself for these patients.