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Endometrial Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (04 / 23 / 2014)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

General Information About Endometrial Cancer

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Understanding Cervical Cancer -- the Basics

Cervical cancer is cancer of the cervix, the narrow neck at the lower part of a woman's uterus, just above the vagina (Figure 1). The cervix connects the uterus to the vagina. Approximately eight out of 10 cervical cancers originate in surface cells lining the cervix (squamous cell carcinomas). These cancers do not form suddenly. Over time, healthy cervical cells can become abnormal in appearance -- this is called dysplasia. Although these cells are not cancerous, they can eventually become...

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Updated statistics with estimated new cases and deaths for 2014 (cited American Cancer Society as reference 1).

Revised text to state that irregular vaginal bleeding is an early sign, the foremost symptom, and the reason why the majority of patients with the highly curable endometrial tumor are diagnosed with stage I disease.

Added text to state that risk factors for the development of endometrial cancer include obesity, hypertension, and diabetes mellitus.

Added text to state that cardiovascular disease is the most common cause of death in patients diagnosed with endometrial cancer because of the early stage of the cancer at diagnosis and the metabolic risk factors (cited Ward et al. as reference 2).

Cellular Classification of Endometrial Cancer

Added text to state that endometrial cancers are classified in one of two categories; namely, type 1 may arise from complex atypical hyperplasia and is pathogenetically linked to unopposed estrogenic stimulation; type 2 develops from atrophic endometrium and is not linked to hormonally driven pathogenesis.

Added text to state that characteristic activating oncogenic mutations or amplification and inactivating mutations or deletion of tumor suppressors are seen more in association with one type of mutation versus the other type, but some overlap exists. Also added that with the Cancer Genome Atlas and a full genetic display of hundreds of endometrial cancers, four subtypes have been identified that will refine classification and provide prognostic and therapeutic implications (cited Kandoth et al. as reference 1).

Stage Information for Endometrial Cancer

Added text to state that even if it no longer influences staging, retrospective data based on the Surveillance, Epidemiology, and End Results Program suggest that positive peritoneal cytology is an independent risk factor in patients with early-stage endometrial cancer (cited Garg et al. as reference 3).

Stage I Endometrial Cancer

Added text to state that uterine serous histologies have higher rates of recurrence than do other stage I endometrioid carcinomas; the outcomes in institutional case series that utilize a policy of adjuvant carboplatin plus paclitaxel, occasionally including radiation therapy, for this histologic subtype, have been published and form the basis of management guidelines (cited Kiess et al., Boruta et al., Huh et al., Fader et al., Kelly et al., Havrilesky et al., and Dietrich et al., as references 1, 2, 3, 4, 5, 6, and 7, respectively). Also added that the Gynecologic Oncology Group (GOG-0249 [NCT00807768]) trial is comparing this chemotherapy regimen to pelvic radiation.

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