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Does Fluoridation Up Bone Cancer Risk?

Study Examines Boyhood Drinking of Fluoridated Water and Possible Links to Osteosarcoma
By
WebMD Health News
Reviewed by Louise Chang, MD

April 6, 2006 - Boys who drink fluoridated water have an increased risk of a deadly bone cancer, a new study suggests.

Elise Bassin, DDS, completed the study in 2001 for her doctoral dissertation at Harvard, where she now is clinical instructor in oral health policy and epidemiology. The study finally was published in the May issue of Cancer Causes and Control.

Bassin and colleagues' major finding: Boys who grew up in communities that added at least moderate levels of fluoride to their water got bone cancer -- osteosarcoma -- more often than boys who drank water with little or no fluoride.

The risk peaked for boys who drank more highly fluoridated water between the ages of 6 and 8 years -- a time at which children undergo a major growth spurt. By the time they were 20, these boys got bone cancer 5.46 times more often than boys with the lowest consumption. No effect was seen for girls.

Unexpected Results

In a prepared statement provided to WebMD, Bassin says she "was surprised by the results."

"Having a background in dentistry and dental public health, [I] was taught that fluoride at recommended levels is safe and effective for the prevention of dental [cavities]," Bassin says in the statement. "All of [our analyses] were consistent in finding an association between fluoride levels in drinking water and an increased risk of osteosarcoma for males diagnosed before age 20, but not consistently for girls."

It's not surprising that Bassin found a risk for boys but not for girls. Osteosarcoma is about 50% more common in males than in females. And boys tend to have more fluoride in their bones than girls.

Caution About Study

However, a commentary accompanying Bassin's article warns to take her findings with a grain of salt. Ironically, it is from Harvard professor Chester W. Douglass, DMD, PhD. Douglass led Bassin's PhD committee, which approved of the study when it was presented as her doctoral dissertation.

Douglass warns that the Bassin study is based only on a subset of people exposed to fluoridated water. Preliminary results from the entire population of exposed individuals, Douglass writes, show no link between bone cancer and water fluoridation.

But Bassin specifically looked at the subgroup of people most likely to be affected by fluoridation: children. She limited her analysis to people who got bone cancer by age 20. That's because most cases of osteosarcoma occur either during the teen years or after middle age.

Fluoride collects in the bones. And it's particularly likely to accumulate in the bones during periods of rapid bone growth. So Bassin looked at fluoride exposures during childhood for 103 under-20 osteosarcoma patients and compared them with 215 matched people without bone cancer. Her study took into account how much fluoride was in the water in the communities where children actually lived and the history of municipal, well water, or bottled water use.

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