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Cancer Health Center

Aspirin May Protect Against Cancer

Advil, Motrin, Nuprin, Aleve Do Not Appear to Have Same Benefits
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WebMD Health News
Reviewed by Louise Chang, MD

April 17, 2007 (Los Angeles) -- Humble aspirin comes through again. Already known to protect against heart disease, the popular painkiller also appears to lower a woman’s risk of developing or dying from cancer, a new study shows.

But other NSAIDs -- nonsteroidal anti-inflammatory drugs -- like Advil, Motrin, Nuprin, and Aleve, do not, the research suggests.

“If you’re already taking aspirin for its heart-protective properties, you may be getting an added benefit,” says researcher Aditya Bardia, MD, MPH, of the Mayo Clinic in Rochester, Minn.

But that doesn’t mean women should start popping aspirin in hopes of warding off cancer, he tells WebMD.

“Aspirin may have anticancer effects, but it also has it own risks, chiefly an increased risk of gastrointestinal bleeding. Talk to your doctor about the risks and benefits,” Bardia says.

Bardia notes that previous studies on the topic have had conflicting results, with some showing that both aspirin and nonaspirin NSAIDs protect against cancer, particularly colon and breast cancer, and others suggesting they do not.

The new study, presented at the annual meeting of the American Association for Cancer Research, is noteworthy both for its large size and long follow-up, he says.

Study Results

The study included 22,507 cancer-free postmenopausal women aged 55 and over who participated in the Iowa Women’s Health Study. At the start of the study, all the women were asked about their use of aspirin and other NSAIDs.

Of the total, 72% said they used aspirin, 39% used nonaspirin NSAIDs, and 28% used both aspirin and nonaspirin NSAIDs.

Over the next 12 years, 3,487 women developed cancer and 3,581 died, including 1,193 who died from cancer. Results showed that those who used aspirin at least once a week were 15% less likely to develop cancer and 9% less likely to die from it than women who never used the painkiller. The more aspirin they took, the greater the benefit: Women who took it six or more times a week were 19% less likely to develop cancer and 18% less likely to die from than nonusers.

But regular use of the other NSAIDs offered no such protection, Bardia says. Additionally, current smokers did not appear to get the same benefits from aspirin, although former and never smokers did, he says.

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