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Liver Cancer Pill Extends Lives

Nexavar Hailed as Breakthrough in Treatment of Advanced Liver Cancer
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WebMD Health News
Reviewed by Louise Chang, MD

June 4, 2007 (Chicago) -- After more than 30 years of research and hundreds of studies, a pill has been shown to extend the lives of people with liver cancer, the third leading cause of cancer death worldwide.

In a study of more than 600 people with advanced liver cancer, those given the drug Nexavar lived nearly three months longer than those given a placebo.

Though three months may not sound like much, doctors say the drug represents a breakthrough that will become the standard of care for people with advanced liver cancer.

Researcher Josep M. Llovet, MD, a liver cancer specialist at both Mount Sinai School of Medicine in New York, and the University of Barcelona in Spain, says that doctors have nothing to offer people whose liver cancers are diagnosed at an advanced stage. In the U.S. and Europe, 40% of liver cancers are diagnosed at a late stage; elsewhere in the world, the figure stands at 70%.

“Now for the first time we have a drug that works in this population,” he tells WebMD.

Study Halted Prematurely

Llovet notes that over the past few decades, tests of dozens of other new drugs have failed. In contrast, the results of the study were so striking that the study was halted prematurely so that all participants could be offered Nexavar.

“This is the first time a treatment has ever been shown to offer this kind of survival advantage to these patients,” says A. William Blackstock, MD, a cancer doctor at Wake Forest University School of Medicine in Winston-Salem, N.C.

He says that typically, people diagnosed with advanced liver cancer have only months to live.

Since Nexavar is already approved for use in the treatment for kidney cancer, doctors are likely to prescribe it “off label” to people with liver cancer while awaiting the FDA to formally approve it for that use, he says.

Blackstock moderated a news briefing at which the findings were released at the annual meeting of the American Society of Clinical Oncology.

Nexavar Well Tolerated

In the study, people with advanced liver cancer were randomly assigned to receive either Nexavar or placebo twice a day.

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