New medications and treatments for pancreatic cancer must be shown to be safe and effective before doctors can prescribe them to patients. Through pancreatic cancer clinical trials, researchers test the effects of new drugs on a group of volunteers with pancreatic cancer. Following a strict protocol and using carefully controlled conditions, researchers evaluate the investigational drugs under development and measure the ability of the new drug to treat pancreatic cancer, its safety, and any possible...
Initially, pancreatic cancer tends to be silent and painless as it grows. By the time it's large enough to cause symptoms, pancreatic cancer has generally grown outside the pancreas. At this point, symptoms depend on the cancer's location within the pancreas:
Pancreatic cancer in the head of the pancreas tends to cause symptoms such as weight loss, jaundice (yellow skin), dark urine, light stool color, itching, nausea, vomiting, abdominal pain, back pain, enlarged lymph nodes in the neck.
Pancreatic cancer in the body or tail of the pancreas usually causes belly and/or back pain and weight loss.
In general, symptoms appear earlier from cancers in the head of the pancreas, compared to those in the body and tail.
Pancreatic Cancer: Gastrointestinal Symptoms
Because pancreatic cancer grows around important areas of the digestive system, gastrointestinal symptoms often predominate:
Abdominal pain. More than 80% of people with pancreatic cancer eventually experience some abdominal pain as the tumor grows. Pancreatic cancer can cause a dull ache in the upper abdomen radiating to the back. The pain may come and go.
Bloating. Some people with pancreatic cancer have a sense of early fullness with meals (satiety) or an uncomfortable swelling in the abdomen.
Pale-colored stools. If the duct draining bile into the intestine is blocked by pancreatic cancer, the stools may lose their brown color and become pale or clay-colored. Urine may become darker.
As it grows and spreads, pancreatic cancer affects the whole body. Constitutional symptoms can include:
Loss of appetite
Elevated blood sugars. Some people with pancreatic cancer develop diabetes as the cancer impairs the pancreas' ability to produce insulin. (However, the vast majority of people with a new diagnosis of diabetes do not have pancreatic cancer.)
Pancreatic Cancer: Skin Symptoms
Jaundice: As pancreatic cancer blocks the duct that releases bile into the intestine (common bile duct), the ingredients of bile build up in the blood. This turns the skin and the eyes yellow, a condition called jaundice. The same blockage causes dark urine and light-colored stools.
Itching: People with pancreatic cancer sometimes report itching all over. Blockage of the bile ducts is often responsible.