Curative surgical excision, by open laparotomy or laparoscopy, is the treatment of choice when possible. The open surgical approach is used if the tumor is suspected to be malignant, since en bloc lymphadenectomy is performed for malignant tumors without distant metastases. Intraoperative ultrasound aids the localization of tumor extent and the relationship to other anatomic structures.
To diagnose pancreatic cancer, a doctor will order certain imaging tests, such as a pancreatic ultrasound or a CT scan of the abdomen. Endoscopic ultrasonography (EUS) uses an ultrasound device connected to the end of a small flexible tube that is inserted into the mouth and is about 85% to 90% accurate in diagnosing pancreatic cancer. If necessary, endoscopic retrograde cholangiopancreatography (ERCP) is used. With ERCP, detailed images are obtained by inserting an endoscope into the mouth to the...
Pharmacologic palliation: diazoxide 300 to 500 mg/day.
Somatostatin analogue therapy.
Patients with hepatic-dominant disease and substantial symptoms caused by tumor bulk or hormone-release syndromes may benefit from procedures that reduce hepatic arterial blood flow to metastases (hepatic arterial occlusion with embolization or with chemoembolization).[6,8,9,10,11,12] Such treatment may also be combined with systemic chemotherapy in selected patients.
Current Clinical Trials
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with insulinoma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
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