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Adult Primary Liver Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular Classification of Adult Primary Liver Cancer

Malignant primary tumors of the liver consist of two major cell types: hepatocellular, which accounts for 90% of cases,[1] and cholangiocarcinoma.

Histologic classification is as follows:

  • Hepatocellular carcinoma (liver cell carcinoma).
  • Hepatocellular carcinoma (fibrolamellar variant). The fibrolamellar variant is important because an increased proportion of the patients may be cured if the tumor can be resected. This variant is found more frequently in young women. It also generally exhibits a slower clinical course than the more common hepatocellular carcinoma.[2]
  • Cholangiocarcinoma (intrahepatic bile duct carcinoma).
  • Mixed hepatocellular cholangiocarcinoma.
  • Undifferentiated.

Hepatoblastoma rarely occurs in adults.

References:

  1. Llovet JM, Burroughs A, Bruix J: Hepatocellular carcinoma. Lancet 362 (9399): 1907-17, 2003.
  2. Mavros MN, Mayo SC, Hyder O, et al.: A systematic review: treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma. J Am Coll Surg 215 (6): 820-30, 2012.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: September 04, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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