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Gallbladder Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - General Information About Gallbladder Cancer

Gallbladder cancer is a disease in which malignant (cancer) cells form in the tissues of the gallbladder.

Gallbladder cancer is a rare disease in which malignant (cancer) cells are found in the tissues of the gallbladder. The gallbladder is a pear-shaped organ that lies just under the liver in the upper abdomen. The gallbladder stores bile, a fluid made by the liver to digest fat. When food is being broken down in the stomach and intestines, bile is released from the gallbladder through a tube called the common bile duct, which connects the gallbladder and liver to the first part of the small intestine.
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Anatomy of the gallbladder. The gallbladder is just below the liver. Bile is stored in the gallbladder and flows through the cystic duct and the common bile duct into the small intestine when food is being digested.

The wall of the gallbladder has 3 main layers of tissue.

  • Mucosal (inner) layer.
  • Muscularis (middle, muscle) layer.
  • Serosal (outer) layer.

Between these layers is supporting connective tissue. Primary gallbladder cancer starts in the inner layer and spreads through the outer layers as it grows.

Being female can increase the risk of developing gallbladder cancer.

Anything that increases your chance of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. Talk with your doctor if you think you may be at risk. Risk factors for gallbladder cancer include the following:

  • Being female.
  • Being Native American.

Possible signs of gallbladder cancer include jaundice, pain, and fever.

These and other symptoms may be caused by gallbladder cancer. Other conditions may cause the same symptoms. Check with your doctor if you have any of the following problems:

  • Jaundice (yellowing of the skin and whites of the eyes).
  • Pain above the stomach.
  • Fever.
  • Nausea and vomiting.
  • Bloating.
  • Lumps in the abdomen.

Gallbladder cancer is difficult to detect (find) and diagnose early.

Gallbladder cancer is difficult to detect and diagnose for the following reasons:

  • There aren't any signs or symptoms that can be seen in the early stages of gallbladder cancer.
  • The symptoms of gallbladder cancer, when present, are like the symptoms of many other illnesses.
  • The gallbladder is hidden behind the liver.
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