Skip to content
My WebMD Sign In, Sign Up

Cancer Health Center

Font Size

Clinical Management of BRCA Mutation Carriers

continued...

Given the conflicting nature of the data and the lack of any clear subset of patients identified to be at risk, at this time there is insufficient evidence of either safety or harm related to short-term use of current formulations of oral contraceptives with regard to breast cancer risk.

Table 9. Oral Contraceptive Pill Use and Breast Cancer Risk in BRCA1/BRCA2 Mutation Carriers

OCP = oral contraceptive pill; CI = confidence interval.
a Reports risk estimates in the form of hazard ratios with 95% confidence intervals.
b Reports risk estimates in the form of odds ratios with 95% confidence intervals.
c Risk estimates restricted to BRCA mutation carriers < age 40 y.
Brohet 2007a[100]Haile 2006b,c[99]Milne 2005b[98]Narod 2002b[97]
Study Population BRCA1 Carriers with Breast CancerN = 597 N = 195; diagnosis < age 50 yN = 47; diagnosis < age 40 yN = 981
BRCA2 Carriers with Breast CancerN = 249 N = 128; diagnosis < age 50 y N = 36; diagnosis < age 40 yN = 330
Ever Use OCP BRCA11.47 [confidence interval [CI] 1.13-1.91] 0.64 [CI 0.35-1.16] 0.22 [CI 0.1-0.49] P < .001 1.38 [CI 1.11-1.72] P = .003a
BRCA21.49 [Cl 0.8-2.7] 1.29 [Cl 0.61-2.76]1.02 [Cl 0.34-3.09]0.94 [Cl 0.72-1.24]
Age Use < 20 yBRCA11.41 [Cl 0.99-2.01] 0.84 [Cl 0.45-1.55]0.26 [Cl 0.11-0.62]1.36 [Cl 1.11-1.67] P = .003
BRCA21.25 [Cl 0.57-2.74] 1.64 [Cl 0.77-3.46]1.40 [Cl 0.44-4.25] Not reported
Total DurationBRCA1< 9 y: 1.51 [Cl 1.1-2.08] < 5 y: 0.61 [Cl 0.31-1.17] < 10 y: 0.22 [Cl 0.09-0.58] < 10 y: 1.36 [Cl 1.11-167] P = .003
BRCA2< 9 y: 2.27 [Cl 1.1-4.65] < 5 y: 0.79 [Cl 0.26-2.37]< 10 y: 1.34 [Cl 0.41-4.45] < 10 y: 0.82 [Cl 0.56-1.91]
Use Before Full-term PregnancyBRCA1> 4 y: 1.49 [Cl 1.05-2.11] > 4 y: 0.69 [Cl 0.41-1.16] Not evaluated Not evaluated
BRCA2> 4 y: 2.58 [Cl 1.21-5.49] > 4 y: 2.08 [Cl 1.02-4.25] trend per year: 1.11; P trend = .01
Use Before 1975BRCA11.48 [Cl 1.11-1.98] Excluded patients who used OCP before 19751.72 [Cl 0.41-7.23] 1.42 [Cl 1.17-1.75] P < .001
BRCA21.36 [Cl 0.71-2.58] 4.18 [Cl 0.8-21.9]
Use After 1975 BRCA11.57 [Cl 1.11-2.22] 0.65 [Cl 0.36-1.19] 0.18 [Cl 0.41-7.23] Not evaluated
BRCA21.53 [Cl 0.75-3.12] 1.21 [Cl 0.56-2.58] 0.92 [Cl 0.3-2.84]
1|2|3|4|5|6|7|8|9|10|11|12|13|14|15|16|17|18|19|20|21|22|23|24|25|26|27|28|29|30|31|32|33|34

WebMD Public Information from the National Cancer Institute

Last Updated: May 16, 2012
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

Today on WebMD

Building a Support System
Blog
cancer fighting foods
SLIDESHOW
 
precancerous lesions slideshow
SLIDESHOW
quit smoking tips
SLIDESHOW
 
Jennifer Goodman Linn self-portrait
Blog
what is your cancer risk
HEALTH CHECK
 
colorectal cancer treatment advances
Video
breast cancer overview slideshow
SLIDESHOW
 
prostate cancer overview
SLIDESHOW
lung cancer overview slideshow
SLIDESHOW
 
ovarian cancer overview slideshow
SLIDESHOW
Actor Michael Douglas
Article