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Penile Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - General Information About Penile Cancer

Penile cancer is a disease in which malignant (cancer) cells form in the tissues of the penis.

The penis is a rod-shaped male reproductive organ that passes sperm and urine from the body. It contains two types of erectile tissue (spongy tissue with blood vessels that fill with blood to make an erection):

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Description of the Evidence

Background Incidence and mortality An estimated 41,380 new cases of oral cancer will be diagnosed in the United States in 2013, and an estimated 7,890 people will die of the disease.[1] This form of cancer accounts for about 3% of cancers in men.[1] The overall annual incidence in the United States is about 10.8 per 100,000 men and women; the median age at diagnosis of oral cavity or pharyngeal cancer was 62 years from 2005 to 2009.[2] Incidence has been falling in men since 1975 and...

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  • Corpora cavernosa: The two columns of erectile tissue that form most of the penis.
  • Corpus spongiosum: The single column of erectile tissue that forms a small portion of the penis. The corpus spongiosum surrounds the urethra (the tube through which urine and sperm pass from the body).

The erectile tissue is wrapped in connective tissue and covered with skin. The glans (head of the penis) is covered with loose skin called the foreskin.

Human papillomavirus infection may increase the risk of developing penile cancer.

Anything that increases your chance of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. Talk with your doctor if you think you may be at risk. Risk factors for penile cancer include the following:

Circumcision may help prevent infection with the human papillomavirus (HPV). A circumcision is an operation in which the doctor removes part or all of the foreskin from the penis. Many boys are circumcised shortly after birth. Men who were not circumcised at birth may have a higher risk of developing penile cancer.

Other risk factors for penile cancer include the following:

  • Being age 60 or older.
  • Having phimosis (a condition in which the foreskin of the penis cannot be pulled back over the glans).
  • Having poor personal hygiene.
  • Having many sexual partners.
  • Using tobacco products.

Possible signs of penile cancer include sores, discharge, and bleeding.

These and other symptoms may be caused by penile cancer. Other conditions may cause the same symptoms. Check with your doctor if you have any of the following problems:

  • Redness, irritation, or a sore on the penis.
  • A lump on the penis.

Tests that examine the penis are used to detect (find) and diagnose penile cancer.

The following tests and procedures may be used:

  • Physical exam and history: An exam of the body to check general signs of health, including checking the penis for signs of disease, such as lumps or anything else that seems unusual. A history of the patient's health habits and past illnesses and treatments will also be taken.
  • Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer.

Certain factors affect prognosis (chance of recovery) and treatment options.

The prognosis (chance of recovery) and treatment options depend on the following:

  • The stage of the cancer.
  • The location and size of the tumor.
  • Whether the cancer has just been diagnosed or has recurred (come back).
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WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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