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    Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

    Localized Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

    Treatment may include the following:

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    • Surgery. Combination chemotherapy is usually given before and after surgery.
    • Surgery followed by radiation therapy when the tumor cannot be completely removed by surgery.

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with localized osteosarcoma and localized childhood malignant fibrous histiocytoma of bone. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

    Metastatic Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

    Lung Metastasis

    When osteosarcoma or malignant fibrous histiocytoma (MFH) spreads, it usually spreads to the lung. Treatment of osteosarcoma and MFH with lung metastasis may include the following:

    Bone Metastasis or Bone with Lung Metastasis

    Osteosarcoma and malignant fibrous histiocytoma may spread to a distant bone and/or the lung. Treatment may include the following:

    • Combination chemotherapy followed by surgery to remove the primary tumor and the cancer that has spread to other parts of the body. More chemotherapy is given after surgery.
    • Surgery to remove the primary tumor followed by chemotherapy and surgery to remove cancer that has spread to other parts of the body.

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with metastatic osteosarcoma and metastatic childhood malignant fibrous histiocytoma of bone. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

    Recurrent Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

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