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Colorectal Cancer Health Center

Medical Reference Related to Colorectal Cancer

  1. Colon Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Treatment Option Overview for Colon Cancer

    Table 6. Standard Treatment Options for Stages 0–III Colon CancerStage (TNM Staging Criteria)Standard Treatment OptionsStage 0 Colon CancerSurgeryStage I Colon CancerSurgeryStage II Colon CancerSurgeryStage III Colon CancerSurgery Adjuvant chemotherapyTable 7. Treatment Options for Stage IV and Recurrent Colon CancerStage (TNM Staging Criteria)Treatment OptionsTreatment of Liver MetastasisSurgeryNeoadjuvant chemotherapyLocal ablationAdjuvant chemotherapyIntra-arterial chemotherapyTreatment of Stage IV and Recurrent Colon CancerSurgeryChemotherapy and targeted therapySecond-line chemotherapyPrimary Surgical TherapyStandard treatment for patients with colon cancer has been open surgical resection of the primary and regional lymph nodes for localized disease.The role of laparoscopic techniques [1,2,3,4] in the treatment of colon cancer has been examined in two studies.Evidence (laparoscopic techniques):A multicenter, prospective, randomized, noninferiority trial

  2. Rectal Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (02 / 08 / 2013)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.General Information About Rectal Cancer Updated statistics with estimated new cases and deaths for 2013 (cited American Cancer Society as reference 1).This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

  3. Rectal Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage II Rectal Cancer

    Treatment options:Preoperative chemoradiation with fluorouracil (5-FU) for patients with clinically staged T3 or T4 rectal adenocarcinoma.Total mesorectal excision (TME) with either low anterior resection (LAR) or abdominoperineal resection (APR).Postoperative chemoradiation for patients with stage II or III rectal cancer who did not receive preoperative chemoradiation.Four to six months of 5-FU-based chemotherapy postoperatively.A clinical trial.Prior to the standard use of preoperative chemoradiation for stage II and III rectal cancer, several studies established the benefits of adjuvant combined-modality therapy for surgical stage II and III disease. Intergroup protocol 86-47-51 (MAYO-864751) demonstrated a 10% improvement in overall survival (OS) with the use of continuous-infusion 5-FU (225 mg/m2 /day throughout the entire course of radiation therapy) compared with bolus 5-FU (500 mg/m2 /day for three consecutive days during the first and fifth weeks of radiation).[1][Level of

  4. Colon Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - About This PDQ Summary

    Purpose of This SummaryThis PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of colon cancer. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.Reviewers and UpdatesThis summary is reviewed regularly and updated as necessary by the PDQ Adult Treatment Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH). Board members review recently published articles each month to determine whether an article should:be discussed at a meeting,be cited with text, orreplace or update an existing article that is already cited.Changes to the summaries are made through a consensus process in which

  5. Colorectal Cancer Screening (PDQ®): Screening - Health Professional Information [NCI] - Summary of Evidence

    Note: Separate PDQ summaries on Prevention of Colorectal Cancer; Colon Cancer Treatment; and Rectal Cancer Treatment are also available. Based on solid evidence,screening for colorectal cancer reduces colorectal cancer mortality,but there is little evidence that it reduces all cause mortality,possibly because of an observed increase in other causes of death. Table 1: Effect of Screening ...

  6. Rectal Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Get More Information From NCI

    Call 1-800-4-CANCERFor more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 8:00 a.m. to 8:00 p.m., Eastern Time. A trained Cancer Information Specialist is available to answer your questions.Chat online The NCI's LiveHelp® online chat service provides Internet users with the ability to chat online with an Information Specialist. The service is available from 8:00 a.m. to 11:00 p.m. Eastern time, Monday through Friday. Information Specialists can help Internet users find information on NCI Web sites and answer questions about cancer. Write to usFor more information from the NCI, please write to this address:NCI Public Inquiries Office9609 Medical Center Dr. Room 2E532 MSC 9760Bethesda, MD 20892-9760Search the NCI Web siteThe NCI Web site provides online access to information on cancer, clinical trials, and other Web sites and organizations that offer support

  7. Colon Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - nci_ncicdr0000062954-nci-header

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Colon Cancer Treatment

  8. Rectal Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular Classification and Pathology of Rectal Cancer

    The World Health Organization (WHO) classification of tumors of the colon and rectum include the following:[1]Epithelial TumorsAdenomaTubular.Villous.Tubulovillous.Serrated.Intraepithelial neoplasia (dysplasia) associated with chronic inflammatory diseasesLow-grade glandular intraepithelial neoplasia.High-grade glandular intraepithelial neoplasia.CarcinomaAdenocarcinoma.Mucinous adenocarcinoma.Signet-ring cell carcinoma.Small cell carcinoma.Adenosquamous carcinoma.Medullary carcinoma.Undifferentiated carcinoma.Carcinoid (well-differentiated neuroendocrine neoplasm)Enterochromaffin (EC)-cell, serotonin-producing neoplasm.L-cell, glucagon-like peptide and pancreatic polypeptide/peptide YY (PYY)-producing tumor.Others.Mixed carcinoma-adenocarcinomaOthers.Nonepithelial TumorsLipoma.Leiomyoma.Gastrointestinal stromal tumor.Leiomyosarcoma.Angiosarcoma.Kaposi sarcoma.Melanoma.Others.Malignant lymphomasMarginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type.Mantle cell

  9. Colorectal Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Colorectal Cancer Screening

    Tests are used to screen for different types of cancer.Some screening tests are used because they have been shown to be helpful both in finding cancers early and decreasing the chance of dying from these cancers. Other tests are used because they have been shown to find cancer in some people; however, it has not been proven in clinical trials that use of these tests will decrease the risk of dying from cancer. Scientists study screening tests to find those with the fewest risks and most benefits. Cancer screening trials also are meant to show whether early detection (finding cancer before it causes symptoms) decreases a person's chance of dying from the disease. For some types of cancer, finding and treating the disease at an early stage may result in a better chance of recovery. Clinical trials that study cancer screening methods are taking place in many parts of the country. Information about ongoing clinical trials is available from the NCI Web site.Studies show that screening for

  10. Rectal Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage III Rectal Cancer

    Treatment options:Preoperative chemoradiation with fluorouracil (5-FU) for patients with clinically staged T3 or T4 rectal adenocarcinoma.Total mesorectal excision (TME) with either low anterior resection (LAR) or abdominoperineal resection (APR).Postoperative chemoradiation for patients with stage II or III rectal cancer who did not receive preoperative chemoradiation.Four to six months of 5-FU-based chemotherapy postoperatively.A clinical trial.Prior to the standard use of preoperative chemoradiation for stage II and III rectal cancer, several studies established the benefits of adjuvant combined-modality therapy for surgical stage II and III disease. Intergroup protocol 86-47-51 (MAYO-864751) demonstrated a 10% improvement in overall survival (OS) with the use of continuous-infusion 5-FU (225 mg/m2 /day throughout the course of radiation therapy) compared with bolus 5-FU (500 mg/m2 /day for 3 consecutive days during the first and fifth weeks of radiation).[1][Level of evidence:

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