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    Diphen-PE-DM-acetaminophen-GG 10 mg(dy)/25 mg-10mg-650mg(nt) powder pk

    precautions

    What should I know regarding pregnancy, nursing and administering Diphen-PE-DM-acetaminophen-GG 10 mg(dy)/25 mg-10mg-650mg(nt) powder pk to children or the elderly?

    If you are:

    Pregnant:

    Possibly Safe:

    Only When Necessary:

    Only When Necessary: EVIDENCE FOR MALFORMATIONS; CAN REDUCE UTERINE BLOOD FLOW CAUSING FETAL HYPOXIA

    Only When Necessary:

    Nursing:

    No Known Risk: LOW LEVELS EXCRETED WITH LOW RISK FOR ADVERSE EFFECTS IN INFANT

    Precaution: INSUFFICIENT DATA AVAILABLE; MOLECULAR WT LOW ENOUGH FOR POSSIBLE EXCRETION

    Precaution: ORAL BIOAVAILABILITY LOW; INFANT EXPOSURE MAY BE MINIMAL

    Precaution: INSUFFICIENT DATA AVAILABLE

    Precaution: LIMITED DATA SUGGEST INCREASED DROWSINESS, AND IRRITABILITY

    An adult over 60:

    management or monitoring precaution: Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.

    management or monitoring precaution: Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Maximum of 25mg/day. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.

    management or monitoring precaution: Hepatic-Elderly are more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose of 3000mg is advised.

    Giving Diphen-PE-DM-acetaminophen-GG 10 mg(dy)/25 mg-10mg-650mg(nt) powder pk to a child under 12:

    management or monitoring precaution: Use weight based dosing in children less than 12 years.

    Contraindication: Do not use in pediatrics <6 years of age unless clinician consultation.

    Severe Precaution: No established efficacy for cough and cold products age < 6 years. Do not use unless directed by clinician consultation.

    Contraindication: Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation.

    Contraindication: Possible risk of CNS excitation, convulsions in newborns.

    Contraindication: Risk of CNS excitation. Do not use age <6 years without clinician consult.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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