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Drugs & Medications

temozolomide

COMMON BRAND NAME(S): Temodar

GENERIC NAME(S): TEMOZOLOMIDE

Uses

This medication is used to treat certain types of brain cancer. It is a chemotherapy drug that works by slowing cancer cell growth. In some patients, temozolomide decreases the size of brain tumors.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat other types of cancer (such as bone cancer).

How to use temozolomide

Read the Patient Information Leaflet provided by your pharmacist before you start using temozolomide and each time you get a refill. If you have any questions about the information or if you are not certain which days of the treatment cycle to take your medication, consult your doctor or pharmacist.

Take this medication by mouth, usually once daily or as directed by your doctor. To reduce nausea and vomiting, take it on an empty stomach (1 hour before or 3 hours after a meal) or at bedtime, unless otherwise directed by your doctor. To make sure the amount of medicine in your body is kept at a constant level, take it at the same time every day in relation to a meal (e.g., always 1 hour before the evening meal or always 3 hours after the evening meal).

Swallow the capsules whole with a full glass of water (8 ounces or 240 milliliters). The dosage is based on your medical condition, body size, and response to therapy.

Do not crush, chew, or open the capsules. If the capsules are accidentally opened or damaged, avoid inhaling the medication, and do not let it touch the skin or mucous membranes (e.g., inside the nose). If contact occurs, flush the area with water. Since this drug can be absorbed through the skin, women who are pregnant or who may become pregnant should not handle this medication.

Do not increase your dose or take this medication more often without your doctor's approval. Your condition will not improve any faster and the risk of serious side effects may be increased.

Side Effects

Nausea, vomiting, loss of appetite, mouth sores, changes in taste, coughing, constipation, tiredness, and headache may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If these effects persist or worsen, tell your doctor or pharmacist promptly.

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

Many people using this medication have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.

This medication may cause very serious blood disorders (such as decreased bone marrow function). It may also rarely cause another form of cancer (of the bone marrow). Consult your doctor for more details. These effects can decrease your body's ability to fight an infection, cause your body to bruise or bleed easier, or cause anemia. Tell your doctor immediately if you develop any of the following: signs of infection (such as fever, persistent sore throat), easy bruising/bleeding, unusual tiredness, fast heartbeat, shortness of breath.

Get medical help right away if you have any very serious side effects, including: seizures, symptoms of liver damage (such as persistent loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine).

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking temozolomide, tell your doctor or pharmacist if you are allergic to it; or to dacarbazine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, decreased bone marrow function, blood cell disorders (e.g., anemia, leukopenia, thrombocytopenia).

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine.

To lower the chance of getting cut, bruised or injured, use caution with sharp objects like safety razors or nail cutters, and avoid activities such as contact sports. Use a soft-bristle toothbrush to lower the risk of bleeding gums.

Wash your hands well to prevent the spread of infections.

The elderly may be more sensitive to the side effects of this drug, especially the increased risk of infection and easy bruising/bleeding.

Women may be more sensitive to the side effects of this drug, especially the increased risk of infection and easy bruising/bleeding.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. It is recommended that men and women use reliable forms of birth control (e.g., condoms and birth control pills) during treatment with this drug. Consult your doctor for more details and to discuss reliable forms of birth control. If you become pregnant or think you may be pregnant, or if your partner becomes pregnant, tell your doctor immediately.

It is not known if this drug passes into breast milk. Due to the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medication because very serious interactions may occur: nalidixic acid.

If you are currently using the medication listed above, tell your doctor or pharmacist before starting temozolomide.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as complete blood count, liver function, brain scan) should be performed before you start treatment, periodically to monitor your progress, or to check for side effects. Consult your doctor for more details.

Missed Dose

For the best benefits, it is important to take each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised May 2014. Copyright(c) 2014 First Databank, Inc.

Images

TEMODAR 5 MG CAPSULE
TEMODAR 5 MG CAPSULE
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TEMODAR 100 MG CAPSULE
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TEMOZOLOMIDE 100 MG CAPSULE
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TEMODAR 140 MG CAPSULE
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TEMOZOLOMIDE 140 MG CAPSULE
TEMOZOLOMIDE 140 MG CAPSULE
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barr 140 mg, 1159
TEMODAR 180 MG CAPSULE
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TEMOZOLOMIDE 180 MG CAPSULE
TEMOZOLOMIDE 180 MG CAPSULE
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TEMODAR 250 MG CAPSULE
TEMODAR 250 MG CAPSULE
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TEMOZOLOMIDE 250 MG CAPSULE
TEMOZOLOMIDE 250 MG CAPSULE
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barr 250 mg, 1075
TEMODAR 5 MG CAPSULE
TEMODAR 5 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a white, oblong capsule imprinted with "TEMOZOLOMIDE" and "logo 5 mg".
TEMOZOLOMIDE 5 MG CAPSULE
TEMOZOLOMIDE 5 MG CAPSULE

Identification

color
off-white
shape
oblong
imprint
barr 5 mg, 1078
This medicine is a off-white, oblong capsule imprinted with "barr 5 mg" and "1078".
TEMODAR 20 MG CAPSULE
TEMODAR 20 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a white, oblong capsule imprinted with "TEMODAR" and "20 mg dp".
TEMOZOLOMIDE 20 MG CAPSULE
TEMOZOLOMIDE 20 MG CAPSULE

Identification

color
off-white
shape
oblong
imprint
barr 20 mg, 1077
This medicine is a off-white, oblong capsule imprinted with "barr 20 mg" and "1077".
TEMODAR 100 MG CAPSULE
TEMODAR 100 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a white, oblong capsule imprinted with "TEMODAR" and "logo 100mg".
TEMOZOLOMIDE 100 MG CAPSULE
TEMOZOLOMIDE 100 MG CAPSULE

Identification

color
off-white
shape
oblong
imprint
barr 100 mg, 1076
This medicine is a off-white, oblong capsule imprinted with "barr 100 mg" and "1076".
TEMODAR 140 MG CAPSULE
TEMODAR 140 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a white, oblong capsule imprinted with "TEMODAR" and "logo 140 mg".
TEMOZOLOMIDE 140 MG CAPSULE
TEMOZOLOMIDE 140 MG CAPSULE

Identification

color
blue
shape
oblong
imprint
barr 140 mg, 1159
This medicine is a blue, oblong capsule imprinted with "barr 140 mg" and "1159".
TEMODAR 180 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a orange, oblong capsule imprinted with "TEMODAR" and "180 mg dp".
TEMOZOLOMIDE 180 MG CAPSULE
TEMOZOLOMIDE 180 MG CAPSULE

Identification

color
dark orange
shape
oblong
imprint
barr 180 mg, 1160
This medicine is a dark orange, oblong capsule imprinted with "barr 180 mg" and "1160".
TEMODAR 250 MG CAPSULE
TEMODAR 250 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a white, oblong capsule imprinted with "TEMODAR" and "logo 250 mg".
TEMOZOLOMIDE 250 MG CAPSULE
TEMOZOLOMIDE 250 MG CAPSULE

Identification

color
off-white
shape
oblong
imprint
barr 250 mg, 1075
This medicine is a off-white, oblong capsule imprinted with "barr 250 mg" and "1075".

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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