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The lungs are a pair of spongy, air-filled organs located on either side of the chest (thorax). The trachea (windpipe) conducts inhaled air into the lungs through its tubular branches, called bronchi. The bronchi then divide into smaller and smaller branches (bronchioles), finally becoming microscopic.
The bronchioles eventually end in clusters of microscopic air sacs called alveoli. In the alveoli, oxygen from the air is absorbed into the blood. Carbon dioxide, a waste product of metabolism, travels from the blood to the alveoli, where it can be exhaled. Between the alveoli is a thin layer of cells called the interstitium, which contains blood vessels and cells that help support the alveoli.
The lungs are covered by a thin tissue layer called the pleura. The same kind of thin tissue lines the inside of the chest cavity -- also called pleura. A thin layer of fluid acts as a lubricant allowing the lungs to slip smoothly as they expand and contract with each breath.
- Chronic obstructive pulmonary disease (COPD): Damage to the lungs results in difficulty blowing air out, causing shortness of breath. Smoking is by far the most common cause of COPD.
- Emphysema: A form of COPD usually caused by smoking. The fragile walls between the lungs' air sacs (alveoli) are damaged, trapping air in the lungs and making breathing difficult.
- Chronic bronchitis: Repeated, frequent episodes of productive cough, usually caused by smoking. Breathing also becomes difficult in this form of COPD.
- Pneumonia: Infection in one or both lungs. Bacteria, especially Streptococcus pneumoniae, are the most common cause, but pneumonia may also be caused by a virus.
- Asthma: The lungs' airways (bronchi) become inflamed and can spasm, causing shortness of breath and wheezing. Allergies, viral infections, or air pollution often trigger asthma symptoms.
- Acute bronchitis: An infection of the lungs' large airways (bronchi), usually caused by a virus. Cough is the main symptom of acute bronchitis.
- Pulmonary fibrosis: A form of interstitial lung disease. The interstitium (walls between air sacs) become scarred, making the lungs stiff and causing shortness of breath.
- Sarcoidosis: Tiny areas of inflammation can affect all organs in the body, with the lungs involved most of the time. The symptoms are usually mild; sarcoidosis is usually found when X-rays are done for other reasons.
- Obesity hypoventilation syndrome: Extra weight makes it difficult to expand the chest when breathing. This can lead to long-term breathing problems.
- Pleural effusion: Fluid builds up in the normally tiny space between the lung and the inside of the chest wall (the pleural space). If large, pleural effusions can cause problems with breathing.
- Pleurisy: Inflammation of the lining of the lung (pleura), which often causes pain when breathing in. Autoimmune conditions, infections, or a pulmonary embolism may cause pleurisy.
- Bronchiectasis: The airways (bronchi) become inflamed and expand abnormally, usually after repeated infections. Coughing, with large amounts of mucus, is the main symptom of bronchiectasis.
- Lymphangioleiomyomatosis (LAM): A rare condition in which cysts form throughout the lungs, causing breathing problems similar to emphysema. LAM occurs almost exclusively in women of childbearing age.
- Cystic fibrosis: A genetic condition in which mucus does not clear easily from the airways. The excess mucus causes repeated episodes of bronchitis and pneumonia throughout life.
- Interstitial lung disease: A collection of conditions in which the interstitium (lining between the air sacs) becomes diseased. Fibrosis (scarring) of the interstitium eventually results, if the process can't be stopped.
- Lung cancer: Cancer may affect almost any part of the lung. Most lung cancer is caused by smoking.
- Tuberculosis: A slowly progressive pneumonia caused by the bacteria Mycobacterium tuberculosis. Chronic cough, fever, weight loss, and night sweats are common symptoms of tuberculosis.
- Acute respiratory distress syndrome (ARDS): Severe, sudden injury to the lungs caused by a serious illness. Life support with mechanical ventilation is usually needed to survive until the lungs recover.
- Coccidioidomycosis: A pneumonia caused by Coccidioides, a fungus found in the soil in the southwestern U.S. Most people experience no symptoms, or a flu-like illness with complete recovery.
- Histoplasmosis: An infection caused by inhaling Histoplasma capsulatum, a fungus found in the soil in the eastern and central U.S. Most Histoplasma pneumonias are mild, causing only a short-lived cough and flu-like symptoms.
- Hypersensitivity pneumonitis (allergic alveolitis): Inhaled dust and other substances cause an allergic reaction in the lungs. Usually this occurs in farmers or others who work with dried, dusty plant material.
- Influenza (flu): An infection by one or more flu viruses causes fever, body aches, and coughing lasting a week or more. Influenza can progress to life-threatening pneumonia, especially in older people with medical problems.
- Mesothelioma: A rare form of cancer that forms from the cells lining various organs of the body with the lungs being the most common. Mesothelioma tends to emerge several decades after asbestos exposure.
- Pertussis (whooping cough): A highly contagious infection of the airways (bronchi) by Bordetella pertussis, causing persistent cough. A booster vaccine (Tdap) is recommended for adolescents and adults to prevent pertussis.
- Pulmonary hypertension: Many conditions can lead to high blood pressure in the arteries leading from the heart to the lungs. If no cause can be identified, the condition is called idiopathic pulmonary arterial hypertension.
- Pulmonary embolism: A blood clot (usually from a vein in the leg) may break off and travel to the heart, which pumps the clot (embolus) into the lungs. Sudden shortness of breath is the most common symptom of a pulmonary embolism.
- Severe acute respiratory syndrome (SARS): A severe pneumonia caused by a specific virus first discovered in Asia in 2002. Worldwide prevention measures seem to have controlled SARS, which has caused no deaths in the U.S.
- SARS-CoV-2/COVID-19: The coronavirus that led to a worldwide pandemic beginning in 2019 can lead to pneumonia that affects both lungs, filling them with fluid and making it difficult to breathe. COVID-19 can lead to long-term lung damage and other respiratory conditions such as acute respiratory distress syndrome.
- Pneumothorax: Air in the chest; it occurs when air enters the area around the lung (the pleural space) abnormally. Pneumothorax can be caused by an injury or may happen spontaneously.
- Chest X-ray: An X-ray is the most common first test for lung problems. It can identify air or fluid in the chest, fluid in the lung, pneumonia, masses, foreign bodies, and other problems.
- Computed tomography (CT scan): A CT scan uses X-rays and a computer to make detailed pictures of the lungs and nearby structures.
- Pulmonary function tests (PFTs): A series of tests to evaluate how well the lungs work. Lung capacity, the ability to exhale forcefully, and the ability to transfer air between the lungs and blood are usually tested.
- Spirometry: Part of PFTs measures how fast and how much air you can breathe out.
- Sputum culture: Culturing mucus coughed up from the lungs can sometimes identify the organism responsible for a pneumonia or bronchitis.
- Sputum cytology: Viewing sputum under a microscope for abnormal cells can help diagnose lung cancer and other conditions.
- Lung biopsy: A small piece of tissue is taken from the lungs, either through bronchoscopy or surgery. Examining the biopsied tissue under a microscope can help diagnose lung conditions.
- Flexible bronchoscopy: An endoscope (flexible tube with a lighted camera on its end) is passed through the nose or mouth into the airways (bronchi). A doctor can take biopsies or samples for culture during bronchoscopy.
- Rigid bronchoscopy: A rigid metal tube is introduced through the mouth into the lungs' airways. Rigid bronchoscopy is often more effective than flexible bronchoscopy, but it requires general (total) anesthesia.
- Magnetic resonance imaging (MRI scan): An MRI scanner uses radio waves in a magnetic field to create high-resolution images of structures inside the chest.
- Thoracotomy: A surgery that enters the chest wall (thorax). Thoracotomy may be done to treat some serious lung conditions or to obtain a lung biopsy.
- Video-assisted thorascopic surgery (VATS): Less-invasive chest wall surgery using an endoscope (flexible tube with a camera on its end). VATS may be used to treat or diagnose various lung conditions.
- Chest tube (thoracostomy): A tube is inserted through an incision in the chest wall in order to drain fluid or air from around the lung.
- Pleurocentesis: A needle is placed into the chest cavity to drain fluid that's around the lung. A sample is usually examined to identify the cause.
- Antibiotics: Medicines that kill bacteria are used to treat most cases of pneumonia. Antibiotics are not effective against viruses.
- Antiviral drugs: When used soon after flu symptoms start, antiviral medicines can reduce the severity of influenza. Antiviral drugs are not effective against viral bronchitis.
- Bronchodilators: Inhaled medicines can help expand the airways (bronchi). This can reduce wheezing and shortness of breath in people with asthma or COPD.
- Corticosteroids: Inhaled or oral steroids can reduce inflammation and improve symptoms in asthma or COPD. Steroids can also be used to treat less common lung conditions caused by inflammation.
- Mechanical ventilation: People with severe attacks of lung disease may require a machine called a ventilator to assist breathing. The ventilator pumps in air through a tube inserted into the mouth or the neck.
- Continuous positive airway pressure (CPAP): Air pressure applied by a machine through a mask keeps the airways open. It is used at night to treat sleep apnea, but it is also helpful for some people with COPD.
- Lung transplant: Surgical removal of diseased lungs and replacement with organ donor lungs. Severe COPD, pulmonary hypertension, and pulmonary fibrosis are sometimes treated with lung transplant.
- Lung resection: A diseased portion of the lung is removed through surgery. Most often, lung resection is used to treat lung cancer.
- Vasodilators: People with some forms of pulmonary hypertension may require long-term medicines to lower the pressure in their lungs. Often, these must be taken through a continuous infusion into the veins.
- Chemotherapy and radiation therapy: Lung cancer is often not curable with surgery. Chemotherapy and radiation therapy can help improve symptoms and sometimes extend life with lung cancer.