Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Fluvoxamine may slow down how quickly your liver processes alosetron.
What might happen:
The amount of alosetron in your blood may increase and cause toxic side effects.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) right away about using these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Lotronex (alosetron hydrochloride) US prescribing information. GlaxoSmithKline March, 2006.
2.Luvox (fluvoxamine maleate) US prescribing information. ANI Pharmaceuticals November, 2012.