Uses
What is Orgovyx used for?
Orgovyx (relugolix) is commonly used for treating advanced prostate cancer.
Orgovyx may also be used for other conditions as determined by your healthcare provider.
How does Orgovyx work (mechanism of action)?
Orgovyx works by attaching itself to certain receptors in the pituitary gland of your brain. By attaching to these receptors, it decreases the release of certain hormones known as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). When these hormones are limited, less testosterone is made in your body. Since most prostate cancer cells need testosterone to grow, Orgovyx helps to block prostate cells from growing.
How is Orgovyx supplied (dosage forms)?
Orgovyx is available as 120 mg oral tablets that are taken by mouth.
How should I store Orgovyx?
Orgovyx should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.
Keep the Orgovyx bottle tightly closed after you open it. This is because it has a desiccant that will protect the medicine from moisture and keep it dry. Do not remove the desiccant from the bottle.
If you have extra Orgovyx leftover when you finish treatment, it is important to dispose of Orgovyx in a community take-back program. You can contact your pharmacy to learn about where you can dispose of Orgovyx in your area. Do not flush the medicine down the toilet.
Side Effects
What are the most common side effects of Orgovyx?
The most common side effects of Orgovyx are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Hot flashes
- Increased blood sugar
- Increased blood fats (triglycerides)
- Muscle or bone pain
- Decreased hemoglobin levels
- Changes in liver function tests
- Tiredness
- Constipation
- Diarrhea
There may be other side effects of Orgovyx that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Orgovyx?
While less common, the most serious side effects of Orgovyx are described below, along with what to do if they happen.
Severe Allergic Reactions. Orgovyx may cause allergic reactions, which can be serious. Stop taking Orgovyx and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Heart Rhythm Changes. Orgovyx may cause a rare, dangerous heart rhythm problem called QT prolongation and torsade de pointes. Some people have a higher risk of this, including people who are older, have other people in their family who have had these conditions, have low potassium or magnesium levels, or who take some medicines for other heart rhythm problems. Tell your healthcare provider right away if you faint or have changes in your heart rate or rhythm, such as a fast or skipping heartbeat.
Warnings & Precautions
Who should not use Orgovyx?
Allergies to Ingredients. People who are allergic to any of the following should not take Orgovyx.
- Relugolix
- Orgovyx
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Orgovyx.
What should I know about Orgovyx before using it?
Do not take Orgovyx unless it has been prescribed to you by a healthcare provider. Take it as prescribed.
Do not share Orgovyx with other people, even if they have the same condition as you. It may harm them.
Swallow Orgovyx whole and do not crush, chew, or split the tablets.
Keep Orgovyx out of the reach of children.
What should I tell my healthcare provider before using Orgovyx?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Orgovyx is right for you.
In particular, make sure that you discuss any of the following.
Current and Past Health Conditions. Tell your healthcare provider if you have any heart problems.
Other Medicines and Supplements. Orgovyx may interact with other medicines and supplements. Before taking Orgovyx, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Pregnancy. Orgovyx may cause harm to an unborn baby. Tell your healthcare provider if you have a partner that can become pregnant. If you are a male who has a female partner that can become pregnant, use effective birth control during treatment with Orgovyx and for 2 weeks after your last dose.
Infertility. Orgovyx may cause fertility problems in people who were assigned male at birth. Talk with your healthcare provider if this is a concern for you.
How can I get more information about Orgovyx?
For more information about Orgovyx, you can visit the manufacturer’s website at www.orgovyx.com or call them at 833-674-6899.
Interactions
Does Orgovyx interact with foods or drinks?
There are no known interactions between Orgovyx and foods or drinks.
There are no known interactions between Orgovyx and alcohol.
Does Orgovyx interact with other medicines (drug interactions)?
Some other medicines may alter the blood levels of Orgovyx, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Orgovyx. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Orgovyx?
If you or someone else has used too much Orgovyx, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Orgovyx?
If you miss a dose, take it as soon as you remember. If it is less than 12 hours before your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.
Are you currently using Orgovyx (relugolix)?
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