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Ixabepilone/Carbamazepine; Phenobarbital; Phenytoin

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Carbamazepine, phenobarbital, and phenytoin may speed up how quickly your liver processes ixabepilone.

What might happen:

The amount of ixabepilone in your blood may decrease and it may not work as well.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together or if you have recently taken carbamazepine, phenobarbital, or phenytoin. Your doctor may want to adjust the dose of your ixabepilone. Let your doctor know right away if you experience any numbness and/or tingling of the hands and/or feet; signs of infection such as fever, chills, cough, or burning/pain on urination; chest pain; difficulty breathing; fast/rapid heart beat; or unusual weight gain.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Ixempra (ixabepilone) US prescribing information. Bristol-Myers Squibb Company October, 2011.


Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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