This medication is used alone or with other medications to help prevent and treat wound infections in patients with severe burns. Mafenide is a drug applied to the skin that belongs to a class of drugs known as sulfa antibiotics. It works by killing bacteria that may infect an open wound. Killing bacteria helps to promote wound healing and to decrease the risk of the bacteria spreading to surrounding skin or to the blood, thereby helping to prevent a serious blood infection (sepsis).
Wash hands before and after using this medication. Use this medication on the skin only. After cleaning the affected area, apply this medication to the wound while wearing a clean pair of medical gloves (e.g., latex, vinyl), usually once or twice daily or as directed by your doctor. The layer of cream should be about one-sixteenth of an inch (1 to 2 millimeters) thick. The wound should be covered with this medication at all times. Bandages do not need to be used to cover the wound. If some of the cream rubs off the wound, re-apply it immediately. Length of treatment is based on your medical condition and response to treatment.
Do not stop using this medication until told to do so by your doctor.
If possible, bathe at least once a day to help remove the dead skin from the wound to allow healing to occur. Be sure to re-apply this medication after bathing.
Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.
Tell your doctor if your condition persists or worsens or if you notice increasing redness/tenderness of the skin around the wound.
Pain, burning, or redness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: blisters, bleeding, fast breathing, nausea, vomiting, diarrhea, headache, change in alertness, shaking (tremors), seizures.
Tell your doctor immediately if any of these rare but very serious side effects occur: weakness, dark urine, stomach/abdominal pain, arm/leg/back pain, fast heartbeat.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Before using mafenide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (including preservatives such as parabens, sulfites), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung problems (e.g., asthma), kidney disease, metabolism problems (e.g., glucose-6-phosphate dehydrogenase deficiency-G6PD), blood disorders.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.
Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms following swallowing may include: diarrhea.
Do not share this medication with others.
This medication has been prescribed for your current condition only. Do not use it later on other wounds unless told to do so by your doctor. A different medication may be necessary in that case.
Laboratory and/or medical tests (e.g., wound cultures, acid-base balance, complete blood counts) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Store at room temperature below 104 degrees F (40 degrees C) away from moisture. Do not store in the bathroom. Keep all medicines away from children and pets.
Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.
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