Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not be able to process tacrolimus properly.
What might happen:
Your blood levels of tacrolimus may increase and cause toxic effects.
What you should do about this interaction:
Contact your doctor if you experience a decrease in the amount of urine you make.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. If your doctor prescribes these medicines together, it may be necessary to adjust the dose of tacrolimus or change you to a different medicine. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Prograf (tacrolimus) Australian prescribing information. Janssen-Cilag Pty Limited December 27, 2000.
2.Prograf (tacrolimus) UK summary of product characteristics. Fujisawa Limited November 14, 2002.
3.Prograf (tacrolimus) US prescribing information. Fujisawa Healthcare, Inc. September, 2013.