Pegademase is used to treat a certain rare genetic immune system problem (severe combined immune deficiency disease-SCID). Pegademase replaces a certain natural substance (an enzyme called adenosine deaminase-ADA) that is missing in people with SCID. This medication increases the number of blood cells that prevent and fight infection (lymphocytes) by helping the body get rid of certain substances that kill lymphocytes.
This medication does not help immune system problems due to other causes (such as AIDS, bone marrow depression).
See also Precautions and Notes sections.
This medication is given by injection into a muscle as directed by your doctor, usually once a week. Do not inject into a vein.
The dosage is based on your medical condition, weight, and response to treatment. Use this medication on schedule so it will work well. Your doctor will order blood tests often to see how it is working for you and find the best dose for you. Keep all medical/lab appointments.
If you are using this medication at home, learn all preparation and usage instructions from your health care professional and the product package. This product should be clear and colorless. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
Your immune system will usually improve slowly, and you should have fewer/less severe infections in 2 to 6 months.
Bleeding/bruising/pain at the injection site and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before using pegademase, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood clotting problems (such as hemophilia, low blood platelets).
This medication may take several weeks or months to work. Even after the medication begins to work, you may still be at increased risk for infection. Ask your doctor how to prevent infection. Wash your hands well, and stay away from people who have an infection.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
One product that may interact with this drug is: vidarabine.
If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Do not share this medication with others.
Laboratory and/or medical tests (such as plasma ADA levels, red blood cell dATP levels) should be performed before you start treatment, periodically to monitor your progress, or to check for side effects. Consult your doctor for more details.
For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule. Do not double the dose to catch up.
Store in the refrigerator. Do not freeze. Discard any unused portion. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised June 2014. Copyright(c) 2014 First Databank, Inc.
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