If you are:
Only When Necessary: CROSSES HUMAN PLACENTA & FOUND IN FETAL TISSUE;MANUFACT. RECOMMENDS NOT USING.
Only When Necessary: RISK OF HYPOGLYCEMIA IN NEONATE IF USED NEAR DELIVERY
Precaution: INSUFFICIENT HUMAN DATA AVAILABLE; ANIMAL DATA SUGGEST EXCRETION
Absolute Contraindication: NOT RECOMMEND;EXCRETED IN RATS; POSSIBILITY OF HYPOGLYCEMIA IN NURSING INFANT
An adult over 60:
management or monitoring precaution: Renal-Decreased renal function increases risk of hypoglycemia. Initiate at low dose, titrate slowly.
management or monitoring precaution: Cardiovascular-Box warning states drug may cause or exacerbate CHF. Contraindicated in patients with NYHA Class III or IV heart failure. Monitor for weight gain, peripheral edema and new onset dyspnea. Hepatic-Monitor for elevations of serum transaminases. Musculoskeletal-Consider increased fracture risk.
Giving Avandaryl tablet to a child under 12:
Severe Precaution: Not recommended in pediatrics. Risk of hypoglycemia and weight gain.
management or monitoring precaution: Insufficient efficacy data to support pediatric use. Pediatric studies demonstrated less effect in lowering fasting glucose from baseline when compared to metformin.