Biodegradable Heart Stent Shows Promise
Magnesium Stent Gradually Absorbed by Blood Vessels; Longer Studies Needed
WebMD News Archive
May 31, 2007 -- Researchers report promising results from a preliminary
study of a new, biodegradable heart stent.
The stent, made of magnesium, widens blocked or narrowed heart arteries and
then fades away within a few months.
The coronary arteries supply blood to heart muscle. Blocked or narrowed
coronary arteries make heart attacks more likely. Heart disease is the No. 1
cause of death for U.S. men and women.
Other types of heart stents are in use, but they have issues that the
biodegradable stent is designed to avoid, researchers report in The
But it's too soon to count on the biodegradable stent as the latest,
greatest treatment for people with heart disease, states an editorial also
published in The Lancet.
Stents are tiny mesh tubes. Doctors insert them into blocked or narrowed
coronary arteries to hold those arteries open.
Some stents are made of bare metal. Other stents are coated with drugs that
release over time.
Permanent stents can have complications. Bare metal stents can get clogged.
Drug-coated stents are designed to help avoid that problem, but recent research
shows they can cause a blood clot to form in the opened artery.
In light of those issues with permanent stents, several research teams are
developing biodegradable stents.
Biodegradable, also called absorbable, stents are intended to last long
enough to widen the blocked or narrowed artery, then gradually dissolve.
WebMD reported on one of those
absorbable stents in March.
Now, a different biodegradable stent is spotlighted in the June 2 edition of
The Lancet. The stent, made of magnesium, is designed to last for four
months before fading away.
Biodegradable Magnesium Heart Stent
The doctors studying the biodegradable magnesium stent included Raimund
Erbel, MD, of the cardiology department at the West German Heart Center in
They implanted the absorbable stents into 63 patients and monitored them for
a year. It was the stent's first test in humans.
None of the patients died or had heart attacks during the yearlong follow-up
However, about 45% of the patients required that their stented artery be
reopened within a year of getting the stent. That includes 24% of the group who
got the stented artery reopened within four months, the time span when the
stent was still supposed to be present.