Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Heartburn/GERD Health Center

Font Size

FDA: Nexium, Prilosec OK for Heart

FDA Finds No Link Between Heart Risks and Long-Term Use of Nexium or Prilosec
WebMD Health News
Reviewed by Louise Chang, MD

Dec. 10, 2007 -- The FDA today confirmed that it sees no likely link between heart attacks or other heart risks and the long-term use of Prilosec and Nexium, which are drugs that treat gastroesophageal reflux disease (GERD).

"We have completed our safety review ... and it is our assessment that the studies do not show a risk for heart attack or heart-related problems," Paul Seligman, MD, said in a press conference. Seligman is the associate director for safety policy and communication at the FDA's Center for Drug Evaluation and Research.

Today's FDA announcement affirms the FDA's initial review of safety data for Nexium and Prilosec. That review, released in August, showed no signs of heart risks associated with long-term use of Nexium or Prilosec.

The FDA began its review in May, when AstraZeneca, the drug company that makes Nexium and Prilosec, sent the FDA data from two long-term studies of GERD patients taking Nexium or Prilosec.

Those studies raised questions about whether long-term use of the drugs increases the risk of heart attacks, heart failure, and heart-related sudden death in patients taking either one of the prescribed drugs compared with patients who got surgical treatment.

The FDA analyzed data from those studies, along with data from additional studies, before issuing today's ruling.

The FDA recommends that "health care providers continue to prescribe, and patients continue to use, these products as described in the labeling for the two drugs," the FDA states in a news release.

Seligman says the FDA hasn't requested any follow-up trials on the issue.

Today on WebMD

Woman eating pizza
How it starts, and how to stop it.
man with indigestion
Get lifestyle and diet tips.
woman shopping for heartburn relief
Medication options.
man with heartburn
Symptoms of both.
digestive health
Heartburn or Heart Attack
Top 10 Heartburn Foods
Is it Heartburn or Gerd
digestive myths
Extreme Eats
graphic of esophageal area