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HIV, AIDS, and the CD4 Count

Factors That Can Affect Your CD4 Count

You should know that other factors can influence how high or low your CD4 count is.

  • CD4 counts tend to be lower in the morning and higher in the evening.
  • Acute illnesses such as pneumonia, influenza, or herpes simplex virus infection can cause CD4 counts to go down for a while.
  • If you have a vaccination or when your body starts to fight an infection, your CD4 counts can go up or down.
  • Cancer chemotherapy can cause CD4 counts to go way down.
  • Fatigue and stress can also affect test results.

For these reasons:

  • Try to use the same lab each time.
  • Have your tests done at the same time of day each time.
  • Wait for at least a couple of weeks after an infection or vaccination before getting a CD count test.

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WebMD Medical Reference

Reviewed by David T. Derrer, MD on August 17, 2014

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