Skip to content

HIV & AIDS Health Center

Font Size

HIV, AIDS, and the CD4 Count

Factors That Can Affect Your CD4 Count

You should know that other factors can influence how high or low your CD4 count is.

  • CD4 counts tend to be lower in the morning and higher in the evening.
  • Acute illnesses such as pneumonia, influenza, or herpes simplex virus infection can cause CD4 counts to go down for a while.
  • If you have a vaccination or when your body starts to fight an infection, your CD4 counts can go up or down.
  • Cancer chemotherapy can cause CD4 counts to go way down.
  • Fatigue and stress can also affect test results.

For these reasons:

  • Try to use the same lab each time.
  • Have your tests done at the same time of day each time.
  • Wait for at least a couple of weeks after an infection or vaccination before getting a CD count test.

WebMD Medical Reference

Reviewed by David T. Derrer, MD on August 17, 2014

Today on WebMD

How much do you know?
contemplative man
What to do now.
Should you be tested?
HIV under microscope
What does it mean?
HIV AIDS Screening
man opening condom wrapper
HIV AIDS Treatment
Discrimination Stigma
Treatment Side Effects
grilled chicken and vegetables
obese man standing on scale
cold sore

WebMD Special Sections